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Triostin A is a complex polyether compound that belongs to the quinomycin family. It is derived from several strains of Streptomyces bacteria and is characterized by its unique macrocyclic structure, which includes a cyclic peptide core connected to two quinone moieties. Triostin A is known for its in-vitro antibacterial and antitumor properties, and it has the ability to interact with double-stranded DNA, making it a potential candidate for cancer therapy.

13758-27-5

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13758-27-5 Usage

Uses

Used in Cancer Therapy:
Triostin A is used as an antitumor agent for its potential in cancer treatment. Its interaction with double-stranded DNA suggests that it could be a promising candidate for therapeutic applications in this field. However, its clinical application has been limited due to its associated toxicity.
Used in Antibacterial Applications:
Triostin A is used as an antibacterial agent for its in-vitro antibacterial properties. It has shown effectiveness against certain bacterial strains, making it a potential candidate for use in the development of new antibiotics.
Used in Drug Delivery Systems:
To overcome the limitations of Triostin A's toxicity, novel drug delivery systems are being developed to enhance its applications and efficacy. Various organic and metallic nanoparticles are being explored as carriers for Triostin A delivery, aiming to improve its delivery, bioavailability, and therapeutic outcomes in both cancer therapy and antibacterial applications.

Check Digit Verification of cas no

The CAS Registry Mumber 13758-27-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,7,5 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13758-27:
(7*1)+(6*3)+(5*7)+(4*5)+(3*8)+(2*2)+(1*7)=115
115 % 10 = 5
So 13758-27-5 is a valid CAS Registry Number.
InChI:InChI=1/C50H62N12O12S2/c1-25(2)39-49(71)73-21-35(57-41(63)33-19-51-29-15-11-13-17-31(29)55-33)43(65)53-28(6)46(68)60(8)38-24-76-75-23-37(47(69)61(39)9)59(7)45(67)27(5)54-44(66)36(22-74-50(72)40(26(3)4)62(10)48(38)70)58-42(64)34-20-52-30-16-12-14-18-32(30)56-34/h11-20,25-28,35-40H,21-24H2,1-10H3,(H,53,65)(H,54,66)(H,57,63)(H,58,64)

13758-27-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name L-Valine, N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl- N-methyl-L-cysteinyl-N-methyl-, bimol. lactone, cyclic disulfide

1.2 Other means of identification

Product number -
Other names N-[(Quinoxalin-2-yl)carbonyl]cyclo[D-Ser*-L-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-[(quinoxalin-2-yl)carbonyl]-D-Ser*-L-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13758-27-5 SDS

13758-27-5Upstream product

13758-27-5Downstream Products

13758-27-5Related news

triostin A (cas 13758-27-5) derived hybrid for simultaneous DNA binding and metal coordination09/27/2019

The natural product triostin A is known as an antibiotic based on specific DNA recognition. Structurally, a bicyclic depsipeptide backbone provides a well-defined scaffold preorganizing the recognition motifs for bisintercalation. Replacing the intercalating quinoxaline moieties of triostin A by...detailed

Sequence preferences in the binding to DNA of triostin A (cas 13758-27-5) and TANDEM as reported by DNase I footprinting09/26/2019

Six or seven triostin-binding sites have been identified in a 160-base-pair DNA restriction fragment containing the tyr T promoter sequence. Each is centred round a CpG step, and the minimum binding site-size appears to be six base pairs. The sites are practically the same as those reported for ...detailed

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