13758-27-5

Basic information

• Product Name: triostin A
• Synonyms: triostin A;N-(2-Quinoxalinylcarbonyl)cyclo[D-Ser*-L-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-(2-quinoxalinylcarbonyl)-D-Ser*-L-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-];N-[(Quinoxalin-2-yl)carbonyl]cyclo[D-Ser*-L-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-N-[(quinoxalin-2-yl)carbonyl]-D-Ser*-L-Ala-N-methyl-L-Cys(1)-N-methyl-L-Val-]
• CAS NO: 13758-27-5
• Molecular Formula: C50H62N12O12S2
• Molecular Weight: 1087.23
• Mol File: 13758-27-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1417.3°Cat760mmHg
• Flash Point: 810.9°C
• Appearance: /
• Density: 1.42g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: triostin A(CAS DataBase Reference)
• NIST Chemistry Reference: triostin A(13758-27-5)
• EPA Substance Registry System: triostin A(13758-27-5)

Safety Data

• RIDADR: 2811
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 13758-27-5(Hazardous Substances Data)

Usage

General Description

Triostin A is a complex polyether compound known for its in-vitro antibacterial and antitumor properties. It is a member of the quinomycin family, derived from several strains of Streptomyces bacteria. This chemical is distinguished by its unique macrocyclic structure, possessing a characteristic cyclic peptide core linked to two quinone moieties. It is notable for its ability to interact with double-stranded DNA, a property that has paved the way for its potential use in cancer therapy. However, its clinical application has been limited due to its associated toxicity.

InChI:InChI=1/C50H62N12O12S2/c1-25(2)39-49(71)73-21-35(57-41(63)33-19-51-29-15-11-13-17-31(29)55-33)43(65)53-28(6)46(68)60(8)38-24-76-75-23-37(47(69)61(39)9)59(7)45(67)27(5)54-44(66)36(22-74-50(72)40(26(3)4)62(10)48(38)70)58-42(64)34-20-52-30-16-12-14-18-32(30)56-34/h11-20,25-28,35-40H,21-24H2,1-10H3,(H,53,65)(H,54,66)(H,57,63)(H,58,64)

Related news

triostin A (cas 13758-27-5) derived hybrid for simultaneous DNA binding and metal coordination09/27/2019

The natural product triostin A is known as an antibiotic based on specific DNA recognition. Structurally, a bicyclic depsipeptide backbone provides a well-defined scaffold preorganizing the recognition motifs for bisintercalation. Replacing the intercalating quinoxaline moieties of triostin A by...detailed

Sequence preferences in the binding to DNA of triostin A (cas 13758-27-5) and TANDEM as reported by DNase I footprinting09/26/2019

Six or seven triostin-binding sites have been identified in a 160-base-pair DNA restriction fragment containing the tyr T promoter sequence. Each is centred round a CpG step, and the minimum binding site-size appears to be six base pairs. The sites are practically the same as those reported for ...detailed