Sequence preferences in the binding to DNA of triostin A (cas 13758-27-5) and TANDEM as reported by DNase I footprinting

Add time:09/26/2019    Source:infona.pl

Six or seven triostin-binding sites have been identified in a 160-base-pair DNA restriction fragment containing the tyr T promoter sequence. Each is centred round a CpG step, and the minimum binding site-size appears to be six base pairs. The sites are practically the same as those reported for echinomycin by DNase I digestion. Only two sites are protected by binding of TANDEM, the des-N-tetramethyl analogue of trios-tin A; they are centred around the sequences ATA or TAT.

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