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1375801-75-4

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1375801-75-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1375801-75-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,5,8,0 and 1 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1375801-75:
(9*1)+(8*3)+(7*7)+(6*5)+(5*8)+(4*0)+(3*1)+(2*7)+(1*5)=174
174 % 10 = 4
So 1375801-75-4 is a valid CAS Registry Number.

1375801-75-4Downstream Products

1375801-75-4Relevant academic research and scientific papers

Novel triazolopyridylbenzamides as potent and selective p38α inhibitors

Aiguadé, Josep,Balagué, Cristina,Carranco, Inés,Caturla, Francisco,Domínguez, María,Eastwood, Paul,Esteve, Cristina,González, Jacob,Lumeras, Wenceslao,Orellana, Adelina,Preciado, Sara,Roca, Ramón,Vidal, Laura,Vidal, Bernat

, p. 3431 - 3436 (2012/06/18)

A new class of p38α inhibitors based on a biaryl-triazolopyridine scaffold was investigated. X-ray crystallographic data of the initial lead compound cocrystallised with p38α was crucial in order to uncover a unique binding mode of the inhibitor to the hinge region via a pair of water molecules. Synthesis and SAR was directed towards the improvement of binding affinity, as well as ADME properties for this new class of p38α inhibitors and ultimately afforded compounds showing good in vivo efficacy.

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