1375830-53-7Relevant academic research and scientific papers
Synthesis and acrosin inhibitory activity of methyl 5-substituted-1H- benzo[d]imidazol-2-yl carbamate derivatives
Liu, Xuefei,Chen, Qianqian,Zhu, Ju,Fan, Yongzheng,Ding, Lili,Zhao, Juntao,Han, Guangqian,Tian, Wei,Qi, Jingjing,Zhou, Youjun,Lv, Jiaguo
scheme or table, p. 3554 - 3559 (2012/06/18)
A series of novel methyl 5-substituted 1H-benzo[d]imidazol-2-ylcarbamates were designed, synthesized, and their acrosin inhibitory activities evaluated in vitro. The results of acrosin inhibitory activity showed that all title compounds were more potent than the control TLCK. Compound 4w displayed the most potent acrosin inhibitory activity among all the compounds, with an IC 50 of 6.3 × 10-5 M. The studies provide a new structural class for the development of novel acrosin inhibitory agents.
