137595-48-3

Basic information

• Product Name: 5-Methoxy-3-methylquinoline
• Synonyms: 5-Methoxy-3-methylquinoline
• CAS NO: 137595-48-3
• Molecular Formula: C11H11NO
• Molecular Weight: 173.21114
• Mol File: 137595-48-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Methoxy-3-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-3-methylquinoline(137595-48-3)
• EPA Substance Registry System: 5-Methoxy-3-methylquinoline(137595-48-3)

Safety Data

• Hazardous Substances Data: 137595-48-3(Hazardous Substances Data)

Upstream product

• 56619-93-3 N-(3-methoxyphenyl)pivalamide 
• 123-38-6 propionaldehyde 
• 82673-65-2 N-(2-formyl-3-methoxyphenyl)pivalamide 
• 68-12-2 N,N-dimethyl-formamide 
• 42588-57-8 3-ethoxymethacrolein 

Relevant articles and documents

Friedlaender Synthesis of Substituted Quinolines from N-Pivaloylanilines

Synthesis of a great variety of quinoline derivatives has been developed by lithiation of N-pivaloylanilines with sec-BuLi, formylation with DMF, and subsequent condensation with active methylene groups of aldehydes or ketones (KHMDS).The pivaloyloxy group is eliminated during one-pot procedure in most cases.The scope of the reaction has been studied, showing that the method is limited by the nature of intermediate compounds. - Keywords: Friedlaender synthesis; pivaloylanilines; quinolines; o-metalation; one-pot synthesis

Synthesis of quinolines via ortho-lithiated N-acylanilines. A modified Friedlander synthesis

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