82673-65-2

Basic information

• Product Name: N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE
• Synonyms: N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE;N-(2-Formyl-3-methoxyphenyl)-2,2-dimethylpropanamide;N-(2-Formyl-3-methoxyphenyl)pivalamide
• CAS NO: 82673-65-2
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.29
• Mol File: 82673-65-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 82-84°
• Appearance: /
• CAS DataBase Reference: N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE(82673-65-2)
• EPA Substance Registry System: N-(2-FORMYL-3-METHOXY-PHENYL)-2,2-DIMETHYL-PROPIONAMIDE(82673-65-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 82673-65-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 30, p. 1257, 1982 DOI: 10.1248/cpb.30.1257

Upstream product

• 3282-30-2 pivaloyl chloride 
• 536-90-3 m-Anisidine 
• 68-12-2 N,N-dimethyl-formamide 
• 56619-93-3 N-(3-methoxyphenyl)pivalamide 

Downstream Products

• 82673-71-0 ethyl (2-methoxy-6-pivaloylamino)cinnamate 
• 6931-19-7 5-methoxyquinoline 
• 911108-90-2 5-hydroxyquinoline-3-carboxylic acid 
• 160893-04-9 5-methoxy-2(1H)-quinolinone 
• 82673-72-1 2'-ethoxycarbonylethyl-3'-methoxy-2,2-dimethylpropionanilide 
• 30557-06-3 3,4-dihydro-5-methoxy-2(1H)-quinolinone 
• 213776-53-5 N-{2-[Bis-(1H-pyrrol-2-yl)-methyl]-3-methoxy-phenyl}-2,2-dimethyl-propionamide 
• 137595-48-3 3-Methyl-5-methoxyquinoline 

Relevant articles and documents

QUINOLONES AS INHIBITORS OF CLASS IV BROMODOMAIN PROTEINS

The present invention provides compounds of formula (I) as described herein and pharmaceutically acceptable salts, hydrates and solvates thereof for use in medicine, for example in the treatment of acute myeloid leukaemia:

Friedlaender Synthesis of Substituted Quinolines from N-Pivaloylanilines

Synthesis of a great variety of quinoline derivatives has been developed by lithiation of N-pivaloylanilines with sec-BuLi, formylation with DMF, and subsequent condensation with active methylene groups of aldehydes or ketones (KHMDS).The pivaloyloxy group is eliminated during one-pot procedure in most cases.The scope of the reaction has been studied, showing that the method is limited by the nature of intermediate compounds. - Keywords: Friedlaender synthesis; pivaloylanilines; quinolines; o-metalation; one-pot synthesis