1375950-82-5

Upstream product

• 1375950-75-6 (2E,8R,10R,12E)-10-(tert-butyldimethylsilyloxy)-8-hydroxy-13-iodo-3,12-dimethyl-1-phenyltrideca-2,12-dien-6-one 
• 1375950-70-1 C₁₆H₃₂OSi₂ 
• 1375950-78-9 ((S)-hept-1-en-6-yn-4-yloxy)(tert-butyl)dimethylsilane 
• 1375950-79-0 ((S,E)-1-iodo-2-methylhepta-1,6-dien-4-yloxy)(tert-butyl)dimethylsilane 
• 1375950-81-4 C₂₉H₄₇IO₄Si 
• 1375950-90-5 (5R,7S,9R)-5-((E)-3-iodo-2-methylallyl)-2,2,3,3,11,11,12,12-octamethyl-9-((E)-3-methyl-5-phenylpent-3-enyl)-4,10-dioxa-3,11-disilatridecan-7-yl acetate 
• 1375950-77-8 (R,E)-3-(tert-butyldimethylsilyloxy)-6-iodo-5-methylhex-5-enal 
• 1375950-80-3 1-((E)-5-iodo-3-methylpent-2-enyl)benzene 
• 1375950-76-7 (E)-5-methyl-7-phenylhept-5-en-2-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 100-39-0 benzyl bromide 
• 209345-84-6 (S)-7-(trimethylsilyl)hept-1-en-6-yn-4-ol 

Downstream Products

• 1375950-74-5 (Z)-((5R,7S,9R)-5-((E)-3-iodo-2-methylallyl)-2,2,3,3,11,11,12,12-octamethyl-9-((E)-3-methyl-5-phenylpent-3-enyl)-4,10-dioxa-3,11-disilatridecan-7-yl) 5-(tert-butyldimethylsilyloxy)-3-iodopent-2-enoate 
• 1375950-83-6 (3E,6E,9E,12R,14S)-12-((tert-butyldimethylsilyl)oxy)-14-((R,E)-2-((tert-butyldimethylsilyl)oxy)-5-methyl-7-phenylhept-5-en-1-yl)-4-(2-hydroxyethyl)-10-methyloxacyclotetradeca-3,6,9-trien-2-one 
• 1375950-73-4 (E)-(5R,7S,9R)-2,2,3,3,11,11,12,12-octamethyl-5-((E)-3-methyl-5-phenylpent-3-en-1-yl)-9-((E)-2-methylhexa-2,5-dien-1-yl)-4,10-dioxa-3,11-disilatridecan-7-yl 3-(2-((tert-butyldimethylsilyl)oxy)ethyl)hexa-2,5-dienoate 
• 1375950-92-7 (3E,6E,9E,12R,14S)-12-((tert-butyldimethylsilyl)oxy)-14-((R,E)-2-((tert-butyldimethylsilyl)oxy)-5-methyl-7-phenylhept-5-en-1-yl)-4-(2-((tert-butyldimethylsilyl)oxy)ethyl)-10-methyloxacyclotetradeca-3,6,9-trien-2-one 
• 1375950-93-8 C₄₂H₆₈O₅Si₂ 
• 1375950-94-9 2-((3E,6E,9E,12R,14S)-12-((tert-butyldimethylsilyl)oxy)-14-((R,E)-2-((tertbutyldimethylsilyl)oxy)-5-methyl-7-phenylhept-5-en-1-yl)-10-methyl-2-oxooxacyclotetradeca-3,6,9-trien-4-yl)acetic acid 

Relevant academic research and scientific papers

Total synthesis of RNA-polymerase inhibitor ripostatin B and 15-deoxyripostatin A

Keep me skipped: A highly convergent total synthesis of ripostatin B, an inhibitor of the bacterial RNA polymerase, is described. The key steps to construct and avoid isomerization of the skipped triene are a double Stille cross-coupling reaction and a ring-closing metathesis. Furthermore, 15-deoxyripostatin A, a stable and conformationally locked analogue of ripostatin A (see scheme, 15-OH group red), was prepared and tested in vivo. Copyright