1375950-87-0Relevant academic research and scientific papers
Total synthesis of RNA-polymerase inhibitor ripostatin B and 15-deoxyripostatin A
Tang, Wufeng,Prusov, Evgeny V.
, p. 3401 - 3404 (2012/06/29)
Keep me skipped: A highly convergent total synthesis of ripostatin B, an inhibitor of the bacterial RNA polymerase, is described. The key steps to construct and avoid isomerization of the skipped triene are a double Stille cross-coupling reaction and a ring-closing metathesis. Furthermore, 15-deoxyripostatin A, a stable and conformationally locked analogue of ripostatin A (see scheme, 15-OH group red), was prepared and tested in vivo. Copyright
