137606-46-3Relevant academic research and scientific papers
Cu-catalyzed N-3-Arylation of Hydantoins Using Diaryliodonium Salts
Neerbye Berntsen, Linn,Nova, Ainara,Wragg, David S.,Sandtorv, Alexander H.
, p. 2687 - 2691 (2020)
A general Cu-catalyzed, regioselective method for the N-3-arylation of hydantoins is described. The protocol utilizes aryl(trimethoxyphenyl)iodonium tosylate as the arylating agent in the presence of triethylamine and a catalytic amount of a simple Cu-salt. The method is compatible with structurally diverse hydantoins and operates well with neutral aryl groups or aryl groups bearing weakly donating/withdrawing elements. It is also applicable for the rapid diversification of pharmaceutically relevant hydantoins.
Synthesis of hydantoins, thiohydantoins, and glycocyamidines under solvent-free conditions
Hashmi, Imran Ali,Aslam, Afshan,Ali, Syed Kashif,Ahmed, Viqar-Uddin,Ali, Firdous Imran
experimental part, p. 2869 - 2874 (2010/11/05)
Hydantoins, thiohydantoins, and glycocyamidines have been prepared in moderate to excellent yields at room temperature under solvent-free conditions. 3N-amino and carboamide derivatives of hydantoin (7-8) were prepared in single step by condensing benzil with semicarbazide and biuret respectively.
New synthetic applications of aryllead triacetates. N-arylation of amides
López-Alvarado, Pilar,Avenda?o, Carmen,Menéndez, J. Carlos
, p. 5865 - 5870 (2007/10/03)
p-Tolyllead triacetate efficiently arylates the nitrogen atom of carboxamide, sulfonamide, imide, and hydantoin anions under mild conditions. This reaction did not interfere with the arylation of amino and β-dicarbonyl groups.
Syntheses of some Heterocyclic Systems Via 1-Cyano-2,2-diphenyl Acrylic Acid Azide
Abdel-Hamid, Hoda A.,Fahmy, A.F.M.,Shiba, S.A.,El-Hawary, N.A.
, p. 167 - 176 (2007/10/02)
1-cyano-2,2-diphenyl acrylic acid azide 1 was used to synthesize a number of condensed and noncondensed heterocyclic systems.Through their conversion to the diaryl urea derivative 2 which cyclises to imidazoles 3, or directly by the reaction with thioglycollic acid to thiazole 4, in the presence of anhydrous aluminium chloride to isoquinoline 5, with hydrazine to triazole 6, with anthranilic acid to quinazoline dione 7, with glycine to oxazole 8 and with semicarbazide to pyrazolidinone 9.All these compounds are of expected biological activity either as pharmaceutical or agrochemicals.
Amide N-Arylation with p-Tolyllead Triacetate
Lopez-Alvarado, Pilar,Avendano, Carmen,Menendez, J. Carlos
, p. 6875 - 6878 (2007/10/02)
The N-arylation of several types of amidic nitrogen atoms, including those found in carboxamides, sulfonamides, carboxylic acid imides, mixed carboxylic-sulfonic imides and hydantoin systems was carried out by treatment of their sodium salts with p-tolyllead triacetate in the presence of copper(II) acetate.
