137612-85-2Relevant academic research and scientific papers
Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2
Syniugin, Anatolii R.,Ostrynska, Olga V.,Chekanov, Maksym O.,Volynets, Galyna P.,Starosyla, Sergiy A.,Bdzhola, Volodymyr G.,Yarmoluk, Sergiy M.
, p. 160 - 169 (2016/12/22)
In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC50 in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives.
Synthesis of Novel Quinobenzodiazepin-12-ones
Rao, K. Rama,Bhanumathi, N.,Sattur, P. B.
, p. 1339 - 1340 (2007/10/02)
The synthesis of potentially biologically active quinobenzodiazepin-12-ones has been reported for the first time by the reaction of 2-chloroquinoline-3-carboxylic acids with o-phenylenediamine.
