137615-36-2

Upstream product

• 137614-78-9 1-(4-(benzyloxy)phenyl)-2,2,2-trifluoroethan-1-one 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1432484-52-0 1-(benzyloxy)-4-(2,2-difluorovinyl)benzene 

Downstream Products

• 86571-21-3 4-(2,2,2-trifluoroethyl)phenol 
• 1073475-15-6 C₂₉H₂₅F₃N₄O₃ 

Relevant academic research and scientific papers

Palladium-Catalyzed Direct Approach to α-Trifluoromethyl Alcohols by Selective Hydroxylfluorination of gem-Difluoroalkenes

A novel palladium-catalyzed selective hydroxylfluorination of gem-difluoroalkenes has been developed. By employing easily obtainable gem-difluoroalkenes and NFSI as the fluorine source, the scope, advantages, and limitations of this reaction were investigated. The reaction presents an efficient synthesis to afford a series of α-trifluoromethyl alcohols in good to excellent yields. Furthermore, this reaction probably proceeds via oxidation of Pd0 to PdII fluoride complex by NFSI, followed by fluoropalladation of gem-difluoroalkenes to generate an α-trifluoromethylbenzyl–Pd intermediate. And this strategy offers more possibilities for the construction of other bonds, such as C–C, C–N and C–S.

PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF

The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of G protein-coupled receptor 119 ("GPR119") in a patient.

Substituted cyclohexylaminopyrimidines

Compounds of formula I where R1is hydrogen, chlorine, fluorine or methyl, R2and R3, which may be the same or different from each other, are hydrogen, halogen, cyano, (C1-C4)-alkyl, vinyl, ethynyl, (C