1376190-36-1Relevant articles and documents
Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold
Zhou, Haibin,Chen, Jianfang,Meagher, Jennifer L.,Yang, Chao-Yie,Aguilar, Angelo,Liu, Liu,Bai, Longchuan,Cong, Xin,Cai, Qian,Fang, Xueliang,Stuckey, Jeanne A.,Wang, Shaomeng
, p. 4664 - 4682 (2012/07/28)
Employing a structure-based strategy, we have designed a new class of potent small-molecule inhibitors of the anti-apoptotic proteins Bcl-2 and Bcl-xL. An initial lead compound with a new scaffold was designed based upon the crystal structure of Bcl-xL an