137623-64-4

Upstream product

• 5874-61-3 4-benzyl-2-phenyl-2-oxazolin-5-one 
• 113548-13-3 N-(benzenesulfonyl)-3-phenyloxaziridine 
• 13909-34-7 N-benzylidenephenylsulfonamide 

Downstream Products

• 143032-90-0 8,10-bis-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-7-(hydroxyacetyl)-3,9,10b-trimethylbenzofuro<2,3-g>-1,2-benzisoxazol-4(10bH)-one 
• 143032-87-5 8,10-bis-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3,9,10b-trimethyl-7-<1-oxo-3-phenyl-3-(phenylsulfonyl)amino>benzofuro<2,3-g>-1,2-benzisoxazol-4(10bH)-one 
• 163458-23-9 Methyl (+/-)-2-hydroxy-3-(2-methyl-1,3-dioxolan-2-yl)propanoate 
• 396100-83-7 (4S,5R,6R)-4,5-bis(tert-butyldimethylsilyloxy)-6-hydroxycyclohex-2-enone 
• 675123-41-8 3-methyl-1,3-diazaspiro[4.4]non-1-en-4-one 

Relevant academic research and scientific papers

Organocatalytic oxyamination of azlactones: Kinetic resolution of oxaziridines and asymmetric synthesis of oxazolin-4-ones

The first example of oxyamination of azlactones with oxaziridines was realized using a chiral bisguanidinium salt. Efficient catalytic asymmetric oxyamination and kinetic resolution of oxaziridines occurred simultaneously. Various chiral oxazolin-4-one derivatives with potential biological activity were obtained (up to 92% ee). Meanwhile, a series of optically pure oxaziridines were recovered with up to 99% ee and successfully used in the asymmetric oxyamination of 3-methyl-1H-indole and styrene. The triple stereodifferentiation process was also studied via control experiments.

ASYMMETRIC SYNTHESIS AND STEREOCHEMICAL PROPERTIES OF OPTICALLY ACTIVE N-SULPHONYL-3-ARYLOXAZIRIDINES

Oxidation of prochiral sulphonimines (RSO2N = CHAr) with (1S)-(+)-PCA, followed by fractional crystallization of the crude reaction products, provides highly optically-pure N-sulphonyl-3-aryloxaziridines 1H-NMR spectra recorded in the presence of chiral solvent or shift reagent, CD spectra, and the results observed by using them as new chiral oxidizing reagents, are also reported.