1376268-49-3Relevant academic research and scientific papers
Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties
Sedgwick, Adam C.,Yan, Kai-Cheng,Mangel, Daniel N.,Shang, Ying,Steinbrueck, Axel,Han, Hai-Hao,Brewster, James T.,Hu, Xi-Le,Snelson, Dylan W.,Lynch, Vincent M.,Tian, He,He, Xiao-Peng,Sessler, Jonathan L.
supporting information, p. 1278 - 1283 (2021/02/01)
Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of iron overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge transfer, and through-bond and through-space conjugation characteristics in aqueous media. Functionalization of the phenol units on the deferasirox scaffold afforded the fluorescent responsive pro-chelator ExPhos, which enabled the detection of the disease-based biomarker alkaline phosphatase (ALP). The diagnostic potential of these deferasirox derivatives was supported by bacterial biofilm studies.
Copper(II)-catalyzed aerobic oxidative synthesis of substituted 1,2,3- and 1,2,4-triazoles from bisarylhydrazones via C-H functionalization/C-C/N-N/C-N bonds formation
Guru, Murali Mohan,Punniyamurthy, Tharmalingam
, p. 5063 - 5073 (2012/07/16)
An unprecedented copper(II)-catalyzed aerobic oxidative synthesis of 2,4,5-triaryl-1,2,3-triazoles and 1,3,5-triaryl-1,2,4-triazoles from bisarylhydrazones as the common starting precursor has been achieved via cascade C-H functionalization/C-C/N-N/C-N bonds formation under mild reaction conditions. One of the enthralling outcomes of this strategy is the copper(II)-catalyzed room temperature C-H functionalization/C-N bond formation in presence of air, which has been accomplished during the synthesis of substituted 1,2,4-triazoles. This new class of compounds could give prospective luminescence as an iconic component in the area of pharmaceutical and biological sciences. The intermediates for both the processes have been isolated to elucidate the mechanistic scenario.
