86245-87-6

Upstream product

• 1218-69-5 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one 
• 100-63-0 phenylhydrazine 
• 86245-83-2 2-(o-hydroxyphenyl)-4-oxo-1,3-benzoxazinium perchlorate 
• 69-72-7 salicylic acid 
• 1972-71-0 2-hydroxy-N-(2-hydroxybenzoyl)benzamide 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 86245-88-7 1-phenyl-3,5-bis(o-acetoxyphenyl)-1,2,4-triazole 
• 110981-90-3 Ni⁽²⁺⁾*C₂N₃(C₆H₅)(C₆H₄O)2^(2-)=Ni(C₂N₃(C₆H₅)(C₆H₄O)2) 
• 110981-89-0 [(3,5-bis(2-oxyphenyl)-1-phenyl-1,2,4-triazole)copper(II)] 
• 110981-91-4 Co⁽²⁺⁾*C₂N₃(C₆H₅)(C₆H₄O)2^(2-)=Co(C₂N₃(C₆H₅)(C₆H₄O)2) 
• 1376268-49-3 3,5-bis(2-methoxyphenyl)-1-phenyl-1H-1,2,4-triazole 

Relevant academic research and scientific papers

Tridentate Complexes of Palladium(II) and Platinum(II) Bearing bis-Aryloxide Triazole Ligands: A Joint Experimental and Theoretical Investigation

A novel class of palladium(II) and platinum(II) complexes bearing tridentate bis-aryloxide triazole ligands was prepared by using straightforward and high-yielding synthetic routes. The complexes were fully characterized and the molecular structures of four derivatives were unambigously determined by single-crystal X-ray diffractometric analyses. For the most promising luminescent PtII derivatives, further experimental investigations were carried out to characterize their photophysical features and to ascertain the nature of the emitting excited state by means of electronic absorption, steady-state, and time-resolved emission techniques in different conditions. In degassed fluid solution the complexes displayed broad and featureless photoluminescence with λem=522-585 nm, excited-state lifetime up to few microseconds and quantum yield (PLQY) up to 17 %, depending on the nature of both ancillary ligand and substituent on the tridentate ligand. Computational investigation using density functional theory and time-dependent DFT were performed to gain insight into the electronic processes responsible for optical transitions and structure-photoluminescence relationship. Jointly, experimental and theoretical characterization indicated that the radiative transition arises from an excited state with admixed triplet-manifold metal-to-ligand charge transfer and ligand-centered (3MLCT/3LC) character. We elucidated the modulation of the photophysical properties upon variation of substituents for this new family of complexes.

Deferasirox (ExJade): An FDA-Approved AIEgen Platform with Unique Photophysical Properties

Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of iron overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge transfer, and through-bond and through-space conjugation characteristics in aqueous media. Functionalization of the phenol units on the deferasirox scaffold afforded the fluorescent responsive pro-chelator ExPhos, which enabled the detection of the disease-based biomarker alkaline phosphatase (ALP). The diagnostic potential of these deferasirox derivatives was supported by bacterial biofilm studies.

CELL ACTIVATABLE IRON CHELATORS

Provided herein are compounds of the formula (I): wherein the variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases or disorders, such as

1,2,4-triazole compound, salt thereof and applications of compound and salt

The invention discloses a 1,2,4-triazole compound, salt thereof and applications of the compound and salt. The compound has a structural formula shown in the description, wherein R represents hydrogen, phenyl or substituted phenyl, and a substituted group of substituted phenyl is selected from carboxyl, an ester group, C1-4 alkyl, C1-4 alkoxy groups, C1-4 halogenated alkyl, C1-4 halogenated alkoxygroups, C2-4 alkynyl, halogen, cyano groups, acyl, nitryl or hydroxyl. The compound has high insecticidal activity for aphids, part of compound has the insecticidal activity for aphids equivalent tothat of a commercial insecticide dinotefuran, and the compound can be used for controlling lepidoptera pests, coleoptera pests, heteropteran pests, diptera pests, orthoptera pests and homoptera pests.

PREPARATION OF NOVEL DEFERASIROX ANALOGUES FOR ANTIMALARIAL ACTIVITY

The present invention relates to processes for the preparation of novel deferasirox analogues for antimalarial activity. The present invention further provides process for synthesis of novel deferasirox analogues.

Complex formation of ICL670 and related ligands with FeIII and FeII

Complex formation of 4-[3,5-bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid (ICL670, H3Lx), 4-[3,5-bis(2-hydroxyphenyl)-1,2,4- triazol-1-yl]benzosulfonic acid (H3Ly), and 3,5-bis(2-hydroxyphenyl)-1-phenyl-1,2,4-triazole (H2Lz) with Fe3+ and Fe2+ was investigated in H2O and in H2O/DMSO mixtures by potentiometry, spectrophotometry and cyclic voltammetry. ICL670 has previously been considered as a promising drug for an oral treatment of iron overload. In this paper, the stability and redox properties of the various FeII and FeIII complexes were elucidated with a particular focus on their potential involvement in the generation of oxidative stress. The overall stability constants of [Fe III(Lx)] and [FeIII(Lx) 2]3- (25 °C, 0.1 M KCl in H2O) are log β1 = 22.0 and log β2 = 36.9, respectively. The affinity of these ligands for Fe2+ is remarkably poor. In particular, the 1:2 complexes [FeIII(Lx)2]4- and [FeII(Ly)2]4- were found to be less stable. As a consequence, the redox chemistry of the [Fe III(Lx)]/[FeII(Lx)]- and the [FeIII(Lx)2]3-/[Fe II(Lx)2]4- couples differs significantly. [FeIII(Lx)2]3- is a very weak oxidizing agent (E1/2 is approximately -0.6 V versus NHE) and reduction of [FeIII(Lx)2]3- is not anticipated under physiological conditions. The reduction potential of the [FeIII(Lx)]/[FeII(Lx)]- couple is considerably less negative and was estimated to be +0.1 V (versus NHE). The possible roles of the various Fe complexes as catalysts for the Fenton reaction in biological media are discussed. The crystal structures of H 3LX, Na[Fe(Lz)2]·4EtOH, Na[Al(Lz)2]· 4EtOH, and [Cu(Lz) (pyridine)]2 were investigated by single-crystal X-ray diffraction, and the possible influence of the particular steric requirements of these ligands on the stability of the metal complexes has been analyzed. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).

SYNTHESIS OF BIS(o-HYDROXYPHENYL)-1,3,5-TRIAZINES, 1,2,4-TRIAZOLES, AND OXADIAZOLE BY RECYCLIZATION OF THE o-HYDROXYPHENYL-4-OXO-1,3-BENZOXAZINIUM CATION

The acidic cyclization of disalicylamide gave 2-(o-hydroxyphenyl)- and 2-(o-acetoxyphenyl)-4-oxo-1,3-benzoxazinium perchlorates, by reaction of which with hydroxylamine, hydrazines, benzamidine, guanidines, and S-methylisothiourea bis(o-hydroxyphenyl)-1,2