1376282-54-0

Upstream product

• 64880-90-6 4′′-methyl-N-[(3,4-methylenedioxyphenyl)ethyl]benzenesulfonamide 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 1485-00-3 5-((E)-2-nitroethenyl)-1,3-benzodioxole 
• 120-57-0 piperonal 

Downstream Products

• 1376282-44-8 5,6,7,8-tetrahydro-5-((E)-prop-1-enyl)-6-tosyl-[1,3]dioxolo[4,5-g]isoquinoline 
• 1376282-46-0 5,6,7,8-tetrahydro-6-tosyl-5-vinyl-[1,3]dioxolo[4,5-g]isoquinoline 
• 1376282-31-3 (E)-3-(5-(2-(tosylamino)ethyl)benzo[d][1,3]-dioxol-6-yl)prop-2-en-1-ol 
• 1376282-29-9 (E)-4-(5-(2-(tosylamino)ethyl)benzo[d][1,3]-dioxol-6-yl)but-3-en-2-ol 
• 1376282-66-4 5,6,7,8-tetrahydro-5-(2-methylprop-1-enyl)-6-tosyl-[1,3]dioxolo[4,5-g]isoquinoline 
• 1376282-34-6 (E)-3-(5-(2-(tosylamino)ethyl)benzo[d][1,3]-dioxol-6-yl)allyl acetate 
• 64388-31-4 1-(4′-methylbenzenesulfonyl)-(5,6-methylenedioxy)-indoline 

Relevant academic research and scientific papers

Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation

A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming process for the preparation of a wide range of benzo-fused heterocyclic scaffolds using iron and copper catalysis is described. Activated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolecular N-or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogues. The general applicability and functional group tolerance of this method were exemplified by the total synthesis of the neolignan natural product, (+)-obtusafuran. DFT calculations using Fukui functions were also performed, providing a molecular orbital rationale for the highly regioselective arene iodination process.