64880-90-6

Upstream product

• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 120-57-0 piperonal 
• 1485-00-3 5-((E)-2-nitroethenyl)-1,3-benzodioxole 

Downstream Products

• 64880-96-2 6-tosyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 64880-97-3 5-methyl-6-(toluene-4-sulfonyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 64881-01-2 5-(4-bromo-phenyl)-6-(toluene-4-sulfonyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline 
• 402717-64-0 phenyl-[6-(toluene-4-sulfonyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-methanone 
• 471908-70-0 (4-methoxy-phenyl)-[6-(toluene-4-sulfonyl)-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-methanone 
• 1428536-56-4 7,8-(1,3-dioxapropane-1,3-diyl)-3-(p-toluenesulfonyl)-1-vinyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 1428536-57-5 8,9-(1,3-dioxapropane-1,3-diyl)-3-(p-toluenesulfonyl)-1-vinyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine 
• 1376282-54-0 C₁₆H₁₆INO₄S 

Relevant academic research and scientific papers

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions

A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.

Synthesis of Functionalized Indolines and Dihydrobenzofurans by Iron and Copper Catalyzed Aryl C-N and C-O Bond Formation

A simple and effective one-pot, two-step intramolecular aryl C-N and C-O bond forming process for the preparation of a wide range of benzo-fused heterocyclic scaffolds using iron and copper catalysis is described. Activated aryl rings were subjected to a highly regioselective, iron(III) triflimide-catalyzed iodination, followed by a copper(I)-catalyzed intramolecular N-or O-arylation step leading to indolines, dihydrobenzofurans, and six-membered analogues. The general applicability and functional group tolerance of this method were exemplified by the total synthesis of the neolignan natural product, (+)-obtusafuran. DFT calculations using Fukui functions were also performed, providing a molecular orbital rationale for the highly regioselective arene iodination process.

THALLIUM IN ORGANIC SYNTHESIS. 67. INTRAMOLECULAR CAPTURE OF AROMATIC RADICAL CATIONS BY AN N-TOSYL GROUP

Radical cations, generated by oxidation of electron-rich arenes by thallium(III) tris(trifluoroacetate), undergo rapid intramolecular capture by an N-tosyl group.