137635-98-4Relevant academic research and scientific papers
Process for preparing uracil derivatives
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, (2008/06/13)
The present invention relates to a novel process for preparing uracil derivatives useful as intermediates in the synthesis of uridines having antiviral or antitumor activity or useful as coadjuvants in antiviral therapy, characterized by converting a compound of the formula II into its mesylate derivative of the formula III which is the reduced to give the desired compound of the formula I: STR1 in which R1 is H, halogen, alkyl, aryl or aralkyl.
SYNTHESIS OF 5-ALKYL SUBSTITUTED URACIL DERIVATIVES FROM BARBITURIC ACID
Candiani, Ilaria,Cabri, Walter,Bedeschi, Angelo,Martinengo, Tiziano,Penco, Sergio
, p. 875 - 879 (2007/10/02)
A new two step synthesis of 5-alkyluracil derivatives from barbituric acids is described.Regioselective mono O-mesylation of barbituric acids, followed by desulfonylation under reductive conditions, afforded uracils in high overall yield.The reductive desulfonylation step is also discussed.
