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Usage

Uses

Used in Agricultural Industry:
6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid is used as a pesticide metabolite for its role in the breakdown of Picolinafen (P436800). 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid is significant in the agricultural industry as it can be traced in crops, providing insights into the presence and impact of the parent pesticide on the environment and food safety.
Used in Environmental Monitoring:
In the field of environmental science, 6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid is used as a marker for monitoring the presence and distribution of Picolinafen in water bodies. Its detection in water samples helps assess the extent of pesticide contamination and informs strategies for mitigating the environmental impact of pesticide use.
Used in Regulatory Compliance:
6-[3-(trifluoromethyl)phenoxy]-2-pyridinecarboxylic acid plays a crucial role in ensuring regulatory compliance within the agricultural and environmental sectors. Its analysis in crops and water samples aids in determining whether the levels of pesticide residues are within the acceptable limits set by regulatory authorities, thus safeguarding public health and the environment.

Upstream product

• 4684-94-0 6-chloropicolinic acid 
• 98-17-9 3-Trifluoromethylphenol 
• 1929-82-4 nitrapyrin 
• 178108-83-3 6-[3-(trifluoromethyl)phenoxy] picolinic acid hydrazide 
• 75-87-6 chloral 
• 178108-95-7 2-cyano-6-[3-(trifluoromethyl)phenoxy] pyridine 
• 136227-55-9 methyl-6-(3-α,α,α-trifluoromethylphenoxy)-picolinate 

Downstream Products

• 222414-73-5 2-[N-(1-(4'-Cyanobenzyl)-1H-imidazol-5-ylethyl)carbamoyl]-6-(3-trifluoromethylphenoxy)pyridine 
• 178108-94-6 6-(3-trifluoromethylphenoxy)pyridine-2-carbonyl chloride 

Relevant academic research and scientific papers

Method for preparing picolinafen

The invention discloses a method for preparing picolinafen, and belongs to the field of pesticide original medicine technology. The method comprises the following steps that (1) 2-chlorine-6-nitrapyrin serves as a raw material, and acid catalysis hydrolysis is carried out to synthesize 2-chlorine-6-pyridine carboxylic acid; (2) under conditions of alkali 1, catalyst and organic solvent 1, etherification reaction is carried out on 2-chlorine-6-pyridine carboxylic acid and m-trifluoromethylphenol to obtain 2-(3-trifluoromethylphenoxy pendant)-6-picolinic acid; (3) the 2-(3-trifluoromethylphenoxypendant)-6-picolinic acid and di(trichloromethyl) dimethyl carboxylate are reacted in alkali 2 and organic solvent 2 to synthesize intermediate 2-(3-trifluoromethylphenoxy pendant)-6-pyridinecarbonylchloride; (4) the intermediate 2-(3-trifluoromethylphenoxy pendant)-6-pyridinecarbonyl chloride and 4-fluoroaniline are reacted in alkali 3 and organic solvent 2 to prepare the picolinafen. The method for preparing the picolinafen has the advantages that the content of the prepared picolinafen product is 98.1%, the yield of the prepared picolinafen product is 83%, synthesis conditions are mild and safe, the operation process is controlled easily, aftertreatment is simple and convenient, the wastewater quantity is less, and the method is a green synthetic method for preparing the picolinafen.

Preparation method of 2-substitured phenoxy-6-pyridine formyl chloride and preparation method for picolinafen

The invention provides a preparation method of 2-substitured phenoxy-6-pyridine formyl chloride and a preparation method for picolinafen. Bis(trichloromethyl) carbonic ester(triphosgene) is used as achloride agent for performing a chloroformylation reaction of 2-(3-trifluoromethylphenoxy)-6-pyridine carboxylic acid. The method is mild in synthesis condition, safe, easy to control an operating process, simple and convenient in post-processing, little in wastewater quantity, and environmentally friendly, and capable of avoiding using corrosive reactants of thionyl chloride and the like, reducing the emission of pollution gases of sulfur dioxide and hydrogen chloride and the like and the emission of wastewater, reducing the requirements to a device, and simplifying the operation, the preparation method is beneficial to improve a preparation method of a picolinafen herbicide, and has the extensive application prospect.

Synthesis method of picolinafen

The invention provides a synthesis method of picolinafen. The synthesis method comprises the following steps: reacting 2-chloro-6-trichloromethyl pyridine (formula II) with 3-trifluoromethyl phenol (formula III) to generate 2-(3-trifluoromethylphenoxyl)-6

Herbicidal carboxamide derivatives

The invention provides compounds of the general formula in whichR1 represents a hydrogen or halogen atom or an alkyl or haloalkyl group;the or each group X independently represents a halogen atom or an optionally substituted alkyl or alkoxy group or an alkenyloxy, alkynyloxy, cyano, carboxy, alkoxycarbonyl, (alkylthio)carbonyl, alkylcarbonyl, amido, alkylamido, nitro, alkylthio, haloalkylthio, alkenylthio, alkynylthio, alkylsulphinyl, alkylsulphonyl, alkyloximinoalkyl or alkenyloximinoalkyl group;n is 0 or an integer from 1 to 5; andL is an alkoxy group.

6-(Nonsubstituted or substituted) phenoxy picolinic acids, process of preparing the same, and agricultural/horticultural germicides containing the same

An agricultural or horticultural fungicide containing 6-(unsubstituted or substituted) phenoxy picolinic acid represented by the general formula (I), as an effective ingredient. wherein R is a halogen atom, a C1to C4alkyl group, a C1to C4haloalkyl group, a C1to C4alkoxy group, a C1to C4haloalkoxy group, a C1to C4alkylthio group, a C1to C4alkylamino group, a di(C1to C4alkyl)amino group or a C7to C8aralkyl(C1to C4alkyl)amino group; n2is an integer of 0 to 3; Y is a C1to C4alkyl group, a C1to C4haloalkyl group, a C1to C4alkoxy group, a C1to C4haloalkoxy group, a C1to C4alkylthio group, a C1to C4haloalkylthio group or a halogen atom; and m is an integer of 0 to 5, and when m and n2are not less than 2, Rs and Ys may be the same or different, respectively. The compound is useful as an effective ingredient of agricultural or horticultural fungicides.

6-phenoxy picolinic acid alkylidene hydrazide derivative, process for producing the same and herbicide using the same

PCT No. PCT/JP98/02842 Sec. 371 Date Feb. 23, 2000 Sec. 102(e) Date Feb. 23, 2000 PCT Filed Jun. 25, 1998 PCT Pub. No. WO99/00370 PCT Pub. Date Jan. 7, 1999A 6-phenoxy picolinic acid alkylidene hydrazide derivative, a process for producing the derivative and a herbicide containing the derivative as an effective ingredient. Such a compound is a novel compound and is useful as an effective ingredient of herbicides.

Herbicidal carboxamide compounds

Compounds of the formula STR1 wherein n is 1 to 5 and the/each X is hydrogen, halogen, cyano, nitro, optionally substituted alkyl or alkoxy alkenyloxy, alkynyloxy, haloalkylthio, alkenylthio or alkynylthio; m is 0 or 1 to 3 and the/each Y is halogen, alkyl or haloalkyl; Z is oxygen or sulphur; and R1 and R2 each, independently, is hydrogen, alkyl optionally substituted by halogen, hydroxy, cyano, alkoxy, alkylthio, alkoxycarbonyl, or mono- or di-alkylamino, alkenyl, alkynyl, hydroxy, alkoxy, alkenyloxy, alkynyloxy, alkoxycarbonyl, amino, mono- or di-alkylamino, alkoxycarbonylamino, arylamino, dialkylcarbamoyl, cycloalkyl, or optionally substituted cycloalkylalkyl; or R1 and R2 together form an alkylene chain optionally interrupted by oxygen, sulphur or --NR--, R being hydrogen or alkyl; are herbicides.

Herbicidal carboxamide derivatives

Compounds of formula STR1 wherein Z is oxygen or sulphur; R1 is hydrogen, halogen, alkyl or haloalkyl; R2 is hydrogen, or alkyl; q is 0 or 1; R3 is hydrogen, alkyl or alkenyl; the or each X independently is halogen, optionally substituted alkyl or alkoxy, alkenyloxy, alkynyloxy, cyano, carboxy, alkoxycarbonyl, (alkylthio)carbonyl, alkylcarbonyl, amido, alkylamido, nitro, alkylthio, haloalkylthio, alkenylthio, alkynylthio, alkylsulphinyl, alkylsulphonyl, alkyloximinoalkyl or alkenyloximinoalkyl; n is 0 or an integer from 1 to 5; the or each Y independently is a halogen, alkyl, nitro, cyano, haloalkyl, alkoxy or haloalkoxy; and m is 0 or an integer from 1 to 5, their preparation and use as herbicides.

Herbicidal carboxamide derivatives

Compounds of formula wherein, Z is oxygen or sulphur;, R1 is hydrogen, halogen, alkyl or haloalkyl;, R2 is hydrogen, or alkyl;, q is 0 or 1;, R3 is hydrogen, alkyl or alkenyl;, the or each X independently is halogen, optionally substituted alkyl or alkoxy, alkenyloxy, alkynyloxy, cyano, carboxy, alkoxycarbonyl, (alkylthio)carbonyl, alkylcarbonyl, amido, alkylamido, nitro, alkylthio, haloalkylthio, alkenylthio, alkynylthio, alkylsulphinyl, alkylsulphonyl, alkyloximinoalkyl or alkenyloximinoalkyl;, n is 0 or an integer from 1 to 5;, the or each Y independently is a halogen, alkyl, nitro, cyano, haloalkyl, alkoxy or haloalkoxy; and m is 0 or an integer from 1 to 5, their preparation and use as herbicides.