137643-48-2Relevant academic research and scientific papers
New synthetic methodology for construction of the 1,3,4,5-tetrahydro-2 H -1,3-benzodiazepin-2-one skeleton
Dengiz, Cagatay,Oezcan, Sevil,Sahin, Ertan,Balci, Metin
experimental part, p. 1365 - 1370 (2010/07/02)
We hereby report a new synthetic methodology for construction of the 1,3,4,5-tetrahydro-2H-1,3-benzodiazepin-2-one skeleton. 2-(2-Carboxyethyl) benzoic acid was converted into the corresponding bis(acyl azide). Curtius rearrangement of the diazide followed by reaction with alcohols provided diurethane derivatives. Ring-closure reaction of the diurethanes with base resulted in formation of the 1,3-benzodiazepin-2-one skeleton. Georg Thieme Verlag Stuttgart · New York.
Catalytic, asymmetric transannular aldolizations: Total synthesis of (+)-hirsutene
Chandler, Carley L.,List, Benjamin
, p. 6737 - 6739 (2008/12/22)
We report an asymmetric, catalytic transannular aldolization that provides polycyclic products useful for natural product synthesis. We found that a proline-derivative catalyzes the transannular aldol reaction of 1,4-cyclooctanediones to the corresponding cyclic β-hydroxy ketones in good yields and with high enantioselectivities. The utility of our reaction has been demonstrated in a total synthesis of (+)-hirustene. Copyright
