1376606-01-7Relevant academic research and scientific papers
Synthesis of α-Keto-1,2,3-triazoles through copper iodide catalyzed oxygenation
Nawratil, Swantje,Grypioti, Maria,Menendez, Christophe,Mallet-Ladeira, Sonia,Lherbet, Christian,Baltas, Michel
, p. 654 - 659 (2014/02/14)
Benzyltriazoles have been catalytically oxidized by using CuI and tert-butyl hydroperoxide to yield phenyl(1H-1,2,3-triazol-4-yl)methanone derivatives in good yields at room temperature. Benzyltriazoles have been catalytically oxidized by using CuI and tert-butyl hydroperoxide to yield phenyl(1H-1,2,3-triazol-4-yl)methanone derivatives in good yields at room temperature. Copyright
Synthesis of α-keto-1,2,3-triazoles through copper iodide catalyzed oxygenation
Nawratil, Swantje,Grypioti, Maria,Menendez, Christophe,Mallet-Ladeira, Sonia,Lherbet, Christian,Baltas, Michel
, p. 654 - 659 (2015/10/05)
Benzyltriazoles have been catalytically oxidized by using CuI and tert-butyl hydroperoxide to yield phenyl(1H-1,2,3-triazol-4-yl)methanone derivatives in good yields at room temperature.
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
Menendez, Christophe,Chollet, Aurélien,Rodriguez, Frédéric,Inard, Cyril,Pasca, Maria Rosalia,Lherbet, Christian,Baltas, Michel
, p. 275 - 283 (2012/07/30)
A series of triazoles have been prepared and evaluated as inhibitors of InhA as well as inhibitors of Mycobacterium tuberculosis H37R v. Several of these new compounds possess a good activity against InhA, particularly compounds 17 and 18 for which molecular docking has been performed. Concerning their activities against M. tuberculosis H 37RV strain, two of them, 3 and 12, were found to be good inhibitors with MIC values of 0.50 and 0.25 μg/mL, respectively. Particularly, compound 12 presenting the best MIC value of all compounds tested (0.6 μM) is totally inactive against InhA.
