1376702-46-3

Upstream product

• 118-72-9 2,6-dimethylbenzene-1-thiol 
• 1376702-15-6 C₁₀H₁₁BrOS 
• 1376702-17-8 C₂₈H₂₅OPS 
• 1376702-21-4 (E)-S-(2,6-dimethylphenyl) 4-hydroxybut-2-enethioate 
• 630-19-3 pivalaldehyde 

Relevant academic research and scientific papers

Asymmetric cycloetherifications by bifunctional aminothiourea catalysts: The importance of hydrogen bonding

Chiral oxacyclic frameworks are prevalent in many natural products and bioactive compounds. In addition, a number of them are important synthetic intermediates. Thus, the synthesis of such structures is a significant goal in the field of organic chemistry. However, the development of catalytic asymmetric cycloetherification for the straightforward synthesis of these compounds remains a challenge. In this study, we propose the use of aminothiourea catalysis as an effective way to accomplish such a challenge. The asymmetric synthesis of chiral oxygen heterocycles, including tetrahydrofurans, tetrahydropyrans, and 1,3-dioxolanes, is demonstrated herein using intramolecular oxy-Michael addition mediated by bifunctional aminothiourea catalysts. Georg Thieme Verlag Stuttgart · New York.

Organocatalytic asymmetric oxy-Michael addition to a γ-hydroxy- α,β-unsaturated thioester via hemiacetal intermediates

We report an asymmetric oxy-Michael addition to a γ-hydroxy-α, β-unsaturated thioester via hemiacetal intermediates in the presence of Cinchona-alkaloid-thiourea-based bifunctional organocatalysts. This method provides a novel enantioselective route to β-hydroxy carboxyl compounds, which in turn can be used to synthesize valuable chiral building blocks.