1376708-05-2Relevant articles and documents
Substituted potassium internal vinyltrifluoroborates: Preparation and use in Suzuki-Miyaura cross-coupling reactions
Math, Shivanand K.,Mokri, Homayoun H.,Lamunyon, James B.,Cefalo, Dustin R.,Testa, Charles A.
supporting information; experimental part, p. 2847 - 2849 (2012/07/17)
A collection of substituted potassium internal vinyltrifluoroborates was prepared and utilized in palladium-catalyzed cross-coupling reactions with aryl and heteroaryl halides. The cross-coupling reactions proceeded readily with Pd(PPh3)4 as a catalyst in toluene/H2O under reflux in the presence of Cs2CO3. The process is regiospecific with regard to the internal vinyltrifluoroborate starting material and tolerates a variety of functional groups. This unique collection of substituted internal vinyltrifluoroborates can be readily utilized in research pharmaceutical applications.