1376770-92-1Relevant articles and documents
Cleavage of 3-aryl-5,6-dihydro-4H-1,2-oxazines using zinc and aqueous chelating ethers: Efficient methodology for N-O bond cleavage
Kumar, P. Sunil,Rai, K. M. Lokanatha
experimental part, p. 440 - 446 (2012/10/07)
A mild and efficient methodology for single pot ring opening of 3-aryl-4H-1,2-oxazines to γ-hydroxy ketones was developed using zinc and aqueous chelating ethers. The ether acts as ligand and co-solvent for the reaction. The ability of zinc ions to form stable complexes with chelating ethers activates the zinc towards reduction. Water is the proton source.