1376936-72-9Relevant academic research and scientific papers
LaCl3·7H2O as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component organic reactions
Umamahesh, Balijapalli,Sathesh, Venkatesan,Ramachandran, Gunasekar,Sathishkumar, Munusamy,Sathiyanarayanan, Kulatu
, p. 895 - 900 (2012)
The three-component one-pot synthesis of highly functionalized piperidine derivatives was carried out by condensing 1,3-dicarbonyl compounds with aromatic aldehydes and aniline using a catalytic amount (10 mol%) of LaCl 3·7H2O in methanol at room temperature. The main features of current protocol include easy work up, mild reaction conditions, good yields and high atom economy. Springer Science+Business Media, LLC 2012.
Synthesis of tetrahydropyridines by one-pot multicomponent reaction using nano-sphere silica sulfuric acid
Daraei, Masoume,Zolfigol, Mohammad Ali,Derakhshan-Panah, Fateme,Shiri, Morteza,Kruger, Hendrik G.,Mokhlesi, Mohammad
, p. 855 - 861 (2015/03/18)
A highly efficient protocol for the synthesis of 1,2,3,4-tetrahydropyridines in the presence of nano-sphere silica sulfuric acid (NS-SSA) was used for good yields by one-pot multicomponent reaction (MCRs). The reagent nano-sphere silica sulfuric acid (NS-SSA) has several advantages, such as easy workup, nontoxicity, convenience and high yields of products.
Al(H2PO4)3 as an efficient and reusable catalyst for the multi-component synthesis of highly functionalized piperidines and dihydro-2-oxypyrroles
Sajadikhah, Seyed Sajad,Hazeri, Nourallah,Maghsoodlou, Malek Taher,Habibi-Khorassani, Sayyed Mostafa,Beigbabaei, Adel,Willis, Anthony C.
, p. 863 - 871 (2013/09/23)
Extremely facile and efficient procedures have been developed for the synthesis of highly functionalized piperidines and dihydro-2-oxypyrroles via one-pot multi-component reactions in the presence of Al(H2PO 4)3 as a heterogeneous and eco-friendly catalyst under mild conditions. The multi-component reaction of aromatic aldehydes, aromatic amines, and β-keto esters catalyzed by Al(H2PO4) 3 in EtOH at room temperature provides highly functionalized piperidines in good to excellent yields. The structure as well as the relative stereochemistry of these functionalized piperidines was confirmed by single X-ray crystallographic analysis. The same catalyst was found useful for the synthesis of polyfuntionalized dihydro-2-oxypyrroles using a four-component reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in MeOH at ambient temperature. It is found that the catalyst is recyclable and can be used up to five times without significant loss of its activity.
