LaCl3·7H2O as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component organic reactions

Article abstract of DOI:10.1007/s10562-012-0829-x

The three-component one-pot synthesis of highly functionalized piperidine derivatives was carried out by condensing 1,3-dicarbonyl compounds with aromatic aldehydes and aniline using a catalytic amount (10 mol%) of LaCl ₃·7H₂O in methanol at room temperature. The main features of current protocol include easy work up, mild reaction conditions, good yields and high atom economy. Springer Science+Business Media, LLC 2012.