13772-94-6

Basic information

• Product Name: 2-Naphthalenamine,5-methoxy-(9CI)
• Synonyms: 2-Naphthalenamine,5-methoxy-(9CI)
• CAS NO: 13772-94-6
• Molecular Formula: C11H11NO
• Molecular Weight: 173.21114
• Product Categories: NAPHTALENE
• Mol File: 13772-94-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 71-72 °C
• Boiling Point: 347.4±15.0 °C(Predicted)
• Appearance: /
• Density: 1.156±0.06 g/cm3(Predicted)
• PKA: 4.12±0.10(Predicted)
• CAS DataBase Reference: 2-Naphthalenamine,5-methoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Naphthalenamine,5-methoxy-(9CI)(13772-94-6)
• EPA Substance Registry System: 2-Naphthalenamine,5-methoxy-(9CI)(13772-94-6)

Safety Data

• Hazardous Substances Data: 13772-94-6(Hazardous Substances Data)

Upstream product

• 345995-27-9 5-methoxy-2-naphthoyl chloride 
• 93-09-4 naphthalene-2-carboxylate 
• 1013-83-8 5-bromonaphthalene-2-carboxylic acid 
• 67878-76-6 5-bromo-2-naphthalenecarboxylic acid methyl ester 
• 848144-71-8 N-boc-2-amino-5-hydroxynaphthalene 
• 23894-12-4 6-aminonaphthalen-1-ol 
• 74-88-4 methyl iodide 
• 32940-15-1 5-methoxy-2-tetralone 
• 1429939-22-9 N-(5-methoxy-3,4-dihydronaphthalen-2-yl)acetamide 
• 77-78-1 dimethyl sulfate 
• 5043-31-2 5-Methoxy-2-naphthoic acid 
• 31108-29-9 1-methoxy-6-nitronaphthalene 

Downstream Products

• 128542-49-4 6-iodo-1-methoxy-naphthalene 

Relevant articles and documents

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Transmembrane protein with unknown function 16/anoctamin-1 (ANO1) is a protein widely expressed in mammalian tissues, and it has the properties of the classic calcium-activated chloride channel (CaCC). This protein has been implicated in numerous major physiological functions. However, the lack of effective and selective blockers has hindered a detailed study of the physiological functions of this channel. In this study, we have developed a potent and selective blocker for endogenous ANO1 in Xenopus laevis oocytes (xANO1) using a drug screening method we previously established (Oh et al., 2008). We have synthesized a number of anthranilic acid derivatives and have determined the correlation between biological activity and the nature and position of substituents in these derived compounds. A structure-activity relationship revealed novel chemical classes of xANO1 blockers. The derivatives contain a-NO2 group on position 5 of a naphthyl group-substituted anthranilic acid, and they fully blocked xANO1 chloride currents with an IC 5050 of 0.08 μM for xANO1. Selectivity tests revealed that other chloride channels such as bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator were not appreciably blocked by 10～30 μM MONNA. The potent and selective blockers for ANO1 identified here should permit pharmacological dissection of ANO1/CaCC function and serve as potential candidates for drug therapy of related diseases such as hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

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