1377455-07-6

Basic information

• Product Name: C₂₁H₂₁F₂N₇O₃S
• Synonyms: C₂₁H₂₁F₂N₇O₃S
• CAS NO: 1377455-07-6
• Molecular Weight: 489.506
• Mol File: 1377455-07-6.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₁F₂N₇O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₁F₂N₇O₃S(1377455-07-6)
• EPA Substance Registry System: C₂₁H₂₁F₂N₇O₃S(1377455-07-6)

Safety Data

• Hazardous Substances Data: 1377455-07-6(Hazardous Substances Data)

Upstream product

• 361336-80-3 methyl 2-(3-amino-2,6-difluorophenyl)acetate 
• 185040-32-8 4-methylamino-2-methylthiopyrimidine-5-carboxaldehyde 
• 69843-13-6 1-methyl-4-aminopyrazole 
• 1377455-14-5 6-(3-amino-2,6-difluorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one 

Relevant articles and documents

The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase

Herein we describe the discovery of a novel series of ATP competitive B-Raf inhibitors via structure based drug design (SBDD). These pyridopyrimidin-7-one based inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. Optimization led to the identification of compound 17, a potent, selective and orally available agent with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies.