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1377455-17-8

C18H18F2N4O3S2 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1377455-17-8 Structure

  • Basic information

    1. Product Name: C18H18F2N4O3S2
    2. Synonyms: C18H18F2N4O3S2
    3. CAS NO:1377455-17-8
    4. Molecular Formula:
    5. Molecular Weight: 440.495
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1377455-17-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C18H18F2N4O3S2(CAS DataBase Reference)
    10. NIST Chemistry Reference: C18H18F2N4O3S2(1377455-17-8)
    11. EPA Substance Registry System: C18H18F2N4O3S2(1377455-17-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1377455-17-8(Hazardous Substances Data)

1377455-17-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1377455-17-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,7,4,5 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1377455-17:
(9*1)+(8*3)+(7*7)+(6*7)+(5*4)+(4*5)+(3*5)+(2*1)+(1*7)=188
188 % 10 = 8
So 1377455-17-8 is a valid CAS Registry Number.

1377455-17-8Relevant articles and documents

The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase

Ren, Li,Ahrendt, Kateri A.,Grina, Jonas,Laird, Ellen R.,Buckmelter, Alex J.,Hansen, Joshua D.,Newhouse, Brad,Moreno, David,Wenglowsky, Steve,Dinkel, Victoria,Gloor, Susan L.,Hastings, Gregg,Rana, Sumeet,Rasor, Kevin,Risom, Tyler,Sturgis, Hillary L.,Voegtli, Walter C.,Mathieu, Simon

, p. 3387 - 3391 (2012/06/18)

Herein we describe the discovery of a novel series of ATP competitive B-Raf inhibitors via structure based drug design (SBDD). These pyridopyrimidin-7-one based inhibitors exhibit both excellent cellular potency and striking B-Raf selectivity. Optimization led to the identification of compound 17, a potent, selective and orally available agent with excellent pharmacokinetic properties and robust tumor growth inhibition in xenograft studies.

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