137758-56-6Relevant academic research and scientific papers
Structure-Activity Relationship and Anticancer Profile of Second-Generation Anti-MRSA Synthetic Retinoids
Cheng, Ana V.,Kim, Wooseong,Escobar, Iliana E.,Mylonakis, Eleftherios,Wuest, William M.
, p. 393 - 397 (2020)
We previously reported the antibacterial activity of CD437, a known antitumor compound. It proved to be a potent antimicrobial agent effective against both growing and persister cells of methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report the synthesis of a panel of analogs and their effect on both MRSA and cancer cells. The hydrophobic group of the parent compound was varied in steric bulk, and lipid-mimicking analogs were tested. Biological assessment confirmed that the adamantane moiety is the most effective substitution for antibacterial activity, and some preferential action in cancer over MRSA was achieved.
Effective synthesis of fluorine-containing phenanthrene bearing hydroxyl group using Mallory reaction and its application for fluorinated polyesters
Kataoka, Shoji,Fukumoto, Hiroki,Kawasaki-Takasuka, Tomoko,Yamazaki, Takashi,Nishimura, Katsuyuki,Agou, Tomohiro,Kubota, Toshio
, p. 84 - 89 (2019)
Mallory reaction of 1,2-bis(4-hydroxyphenyl)-3,3,4,4,5,5-hexafluorocyclopentene under light irradiation (λ = 356 nm) in the presence of iodine as an oxidant proceeded to give fluorine-containing phenanthrene bearing hydroxyl groups, 6,9-bis(4-hydroxyphenyl)-1,1,2,2,3,3-hexafluoro-2,3-dihydro-1H-cyclopenta[l]phenanthrene. Polycondensation of the prepared fluorine-containing phenanthrene with various acid dichlorides afforded the phenanthrene-type polyesters. For comparison, diarylethene-type polyesters were also prepared analogously. Diarylethene-type polyesters consisting m-phenylene unit showed good solubility in typical organic solvents such as CHCl3. Tetramethylene-linked diarylethene-type polyesters with Mn = 4100 (Mn = number average molecular weight) was isolated as oil. Other diarylethene-type and all phenanthrene-type polyesters were insoluble in organic solvents. The phenanthrene-type polyesters had high thermal stability revealed by TGA analysis.
Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors
Kim, Boyoung,Park, Hwanggue,Lee, Seul Ki,Park, Sung Jean,Koo, Tae-Sung,Kang, Nam Sook,Hong, Ki Bum,Choi, Sungwook
, p. 777 - 787 (2016/08/23)
Wild type transthyretin (TTR) and mutant TTR misfold and misassemble into a variety of extracellular insoluble amyloid fibril and/or amorphous aggregate, which are associated with a variety of human amyloid diseases. To develop potent TTR amyloidogenesis
