592466-63-2Relevant academic research and scientific papers
Systemic optimization and structural evaluation of quinoline derivatives as transthyretin amyloidogenesis inhibitors
Kim, Boyoung,Park, Hwanggue,Lee, Seul Ki,Park, Sung Jean,Koo, Tae-Sung,Kang, Nam Sook,Hong, Ki Bum,Choi, Sungwook
, p. 777 - 787 (2016/08/23)
Wild type transthyretin (TTR) and mutant TTR misfold and misassemble into a variety of extracellular insoluble amyloid fibril and/or amorphous aggregate, which are associated with a variety of human amyloid diseases. To develop potent TTR amyloidogenesis
Non-imidazole heterocyclic histamine H3 receptor antagonists
Chai, Wenying,Breitenbucher, J. Guy,Kwok, Annette,Li, Xiaobing,Wong, Victoria,Carruthers, Nicholas I.,Lovenberg, Timothy W.,Mazur, Curt,Wilson, Sandy J.,Axe, Frank U.,Jones, Todd K.
, p. 1767 - 1770 (2007/10/03)
Continued exploration of the SAR around the lead imidazopyridine histamine H3 antagonist 1 has led to the discovery of several related series of heterocyclic histamine H3 antagonists. The synthesis and SAR of indolizine, indole and p
