137764-80-8Relevant academic research and scientific papers
AN EFFICIENT PREPARATION OF OPTICALLY ACTIVE (E)-γ-HYDROXY-α,β-UNSATURATED PHENYL SULFONES USING LIPASE-MEDIATED ACYLATIONS
Dominguez, Esteban,Carretero, Juan Carlos,Fernandez-Mayoralas, Alfonso,Conde, Santiago
, p. 5159 - 5162 (1991)
(E)-γ-Hydroxy-α,β-unsaturated phenyl sulfones have been efficiently resolved via irreversible enzymatic acylation with Lipase PS (Pseudomonas cepacia) and vinyl acetate.This process has been applied to the synthesis of the aggregation pheromone (-)-(3S,4S)-4-methyl-3-heptanol.
SINTESIS ENANTIOSELECTIVA DEL FRAGMENTO C9-C13 DE LA ERITROMICINA B
Dominguez, E.,Carretero, J. C.
, p. 397 - 402 (2007/10/02)
A stereocontrolled synthesis of the enantiomerically pure C9-C13 fragment of erythromycin B is described.The process takes place in 15 steps from (R)-phenylsulfonyl p-tolylsulfinyl methane and butyraldehyde (16percent overall yield).The key steps, corresponding to the formation of the chiral centers, are based on the iterative synthesis of γ-hydroxyvinylsulfones and further syn-stereoselective addition of MeLi to their protected derivatives.
