1377823-90-9

Upstream product

• 88-72-2 1-methyl-2-nitrobenzene 
• 1352790-94-3 (R)-(2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methanol 
• 1352790-93-2 (S)-methyl 2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidine-4-carboxylate 
• 159155-12-1 (S)-methyl 3-hydroxy-2-(2,4,6-triisopropylphenylsulfonamido)propanoate 
• 6553-96-4 2,4,6-triisopropylphenylsulfonyl chloride 
• 1377824-27-5 (S)-1-(2-((E)-(((R)-2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)oxazolidin-4-yl)methylene)amino)phenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid 
• 1377823-88-5 (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)oxazolidin-4-yl)methylene)-4-methylaniline oxide 
• 1377823-84-1 (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)oxazolidin-4-yl)methylene)-4-(trifluoromethyl)aniline oxide 
• 1377823-82-9 (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)oxazolidin-4-yl)methylene)-4-fluoroaniline oxide 
• 1352790-96-5 (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidin-4-yl)methylene)aniline oxide 
• 1352790-95-4 (S)-2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidine-4-carbaldehyde 
• 611-22-3 N-(o-tolyl)hydroxylamine 

Downstream Products

• 1377823-82-9 (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)oxazolidin-4-yl)methylene)-4-fluoroaniline oxide 
• 1377823-84-1 (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)oxazolidin-4-yl)methylene)-4-(trifluoromethyl)aniline oxide 
• 1377823-88-5 (R,Z)-N-((2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)oxazolidin-4-yl)methylene)-4-methylaniline oxide 
• 1352790-95-4 (S)-2,2-dimethyl-3-((2,4,6-triisopropylphenyl)sulfonyl)-1,3-oxazolidine-4-carbaldehyde 
• 1377824-57-1 (S)-7'-methoxy-7-methyl-3',4'-dihydro-2'H-spiro[indoline-3,1'-naphthalen]-2-one 

Relevant academic research and scientific papers

An asymmetric pericyclic cascade approach to 3-alkyl-3-aryloxindoles: Generality, applications and mechanistic investigations

The reaction of L-serine derived N-arylnitrones with alkylarylketenes generates asymmetric 3-alkyl-3-aryloxindoles in good to excellent yields (up to 93%) and excellent enantioselectivity (up to 98% ee) via a pericyclic cascade process. The optimization, scope and applications of this transformation are reported, alongside further synthetic and computational investigations. The preparation of the enantiomer of a Roche anti-cancer agent (RO4999200) 1 (96% ee) in three steps demonstrates the potential utility of this methodology.

Asymmetric pericyclic cascade approach to spirocyclic oxindoles

The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90-99% ee) via a pericyclic cascade process.