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(5-(4-fluorobenzyl)-2,3,4-trimethoxyphenyl)(4-(quinolin-8-yloxy)phenyl)methanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1377834-33-7

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1377834-33-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1377834-33-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,7,8,3 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1377834-33:
(9*1)+(8*3)+(7*7)+(6*7)+(5*8)+(4*3)+(3*4)+(2*3)+(1*3)=197
197 % 10 = 7
So 1377834-33-7 is a valid CAS Registry Number.

1377834-33-7Relevant academic research and scientific papers

Structure-activity relationship of selected polyphenol derivatives as inhibitors of Bax/Bcl-xL interaction

Vo, Duc Duy,Gautier, Fabien,Juin, Philippe,Grée, René

, p. 286 - 293 (2012/07/14)

This paper describes the synthesis of nine selected diaryl/heteroaryl- containing phenol and polyphenol derivatives which have been evaluated against Bax/Bcl-xL interaction in comparison with ABT-737. Using a BRET assay, six of these derivatives exhibit activity comparable to ABT-737 to disrupt Bax/Bcl-xL interaction. These preliminary results demonstrate that such polyphenol-derived molecules are attractive compounds regarding anticancer activity and that the phenol at position 3 is important regarding disruption of Bax/Bcl-xL interaction.

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