137789-31-2

Upstream product

• 24509-26-0 (R)-2-Allyl-4-methyl-pent-4-en-1-ol 
• 137298-87-4 ((R)-2-Allyl-4-methyl-pent-4-enyloxymethyl)-benzene 
• 137298-86-3 (4S,5R)-3-((R)-2-Allyl-4-methyl-pent-4-enoyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 130256-39-2 Acetic acid (1S,3S,5R)-3-benzyloxymethyl-5-hydroxy-cyclohexyl ester 

Downstream Products

• 128684-91-3 (1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane 
• 122948-78-1 (1R,2R,4R)-4-<(E)-2-bromo-1-propen-1-yl>-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane 
• 137265-57-7 (1R,2R,4R)-4-Benzyloxymethyl-2-methoxy-cyclohexanol 
• 137298-84-1 C₇₄H₁₃₈O₉S₂Si₃ 
• 137298-84-1 C₇₄H₁₃₈O₉S₂Si₃ 
• 109466-73-1 (-)-(1R,2R,4R)-4-hydroxymethyl-2-methoxycyclohexan-1-ol 
• 145373-33-7 Thiocarbonic acid O-((3R,3aR,6R,7aR)-3-methyl-2-oxo-octahydro-benzofuran-6-ylmethyl) ester O-phenyl ester 
• 145373-33-7 Thiocarbonic acid O-((3S,3aR,6R,7aR)-3-methyl-2-oxo-octahydro-benzofuran-6-ylmethyl) ester O-phenyl ester 
• 137839-85-1 Thiocarbonic acid O-((3aS,6R,7aS)-2-oxo-octahydro-benzofuran-6-ylmethyl) ester O-phenyl ester 
• 145373-28-0 (3S,6R,7aS,8S)-3,6-dimethyl-3-phenylseleno-2(3H)-benzofuranone 
• 137839-85-1 Thiocarbonic acid O-((3aR,6R,7aR)-2-oxo-octahydro-benzofuran-6-ylmethyl) ester O-phenyl ester 
• 137819-29-5 (3R,3aS,6R,7aR)-3,6-Dimethyl-3-phenylselanyl-hexahydro-benzofuran-2-one 
• 137819-27-3 (3aR,6R,7aR)-6-Benzyloxymethyl-hexahydro-benzofuran-2-one 
• 137789-33-4 (3aR,6R,7aR)-6-Benzyloxymethyl-2-ethoxy-octahydro-benzofuran 

Relevant academic research and scientific papers

Revision of the enantiotoposelective PLE-catalyzed hydrolysis of cis-5-substituted-1,3-diacyloxycyclohexanes

Revision of previous work shows that PLE-catalyzed hydrolysis of 1 leads to the (S)-alcohol 5 and not the (R)-alcohol 3.However the homologue 2 gives the (R)-alcohol 4.

Synthetic studies towards the immunosuppressant FK-506 synthesis of the C10-C34 fragment

The synthesis of the cyclohexyl moiety of FK-506 and its coupling reaction with the C10-C26 fragment to provide an advanced synthetic intermediate(C10-C34) are described.