1377934-76-3

Upstream product

• 66684-58-0 3,4,5-trifluoronitrobenzene 
• 1377934-73-0 methyl 2-(4-bromo-2,6-difluorophenyl)propanoate 
• 544-97-8 dimethyl zinc(II) 
• 1377934-70-7 methyl 2-(4-amino-2,6-difluorophenyl)propanoate 
• 1377934-67-2 methyl 2-(2,6-difluoro-4-nitrophenyl)propanoate 
• 1226776-82-4 2-(2,6-difluoro-4-nitrophenyl)propanoic acid 

Downstream Products

• 1377934-80-9 methyl 2-[4-(bromomethyl)-2,6-difluorophenyl]propanoate 

Relevant academic research and scientific papers

2-FLUOROPHENYL PROPIONIC ACID DERIVATIVES

Provided are novel 2-fluorophenyl propionic acid derivatives which have excellent anti-inflammatory/analgesic effects while avoiding side effects such as gastrointestinal disorders, namely 2-fluorophenyl propionic acid derivatives represented by the formula (I) below or pharmaceutically acceptable salts thereof, [wherein, R1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group, X represents —CH2—, —NH—, —O—, or —S—, and Y specifically represents group (II) (wherein, Z1 represents —CO—, —CH(OH)—, or —CH2—, and n represents an integer of 1 or 2.)]

Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2- oxocyclopentyl)methyl]phenyl}propanoic acid: Nonsteroidal anti-inflammatory drugs with low gastric ulcerogenic activity

We previously reported that 2-fluoroloxoprofen has lower gastric ulcerogenic activity than loxoprofen, a nonsteroidal anti-inflammatory drug (NSAID) without selectivity for COX-2. We synthesized derivatives of 2-fluoroloxoprofen and studied their properti