1378078-18-2

Upstream product

• 98-88-4 benzoyl chloride 
• 532-55-8 Benzoyl isothiocyanate 
• 3694-52-8 2,3-diamino-nitrobenzene 

Downstream Products

• 1378075-89-8 N₂-(2-Methoxy-phenyl)-6H-imidazo[4',5':3,4]benzo[2,1-d]thiazole-2,7-diamine 
• 1378078-66-0 N-{4-[3-(2-Methoxy-phenyl)-thioureido]-1H-benzoimidazol-2-yl}-benzamide 
• 1378078-29-5 N-(4-Amino-1H-benzoimidazol-2-yl)-benzamide 

Relevant academic research and scientific papers

Copper promoted C-S and C-N cross-coupling Reactions:The synthesis of 2-(N-Aryolamino)benzothiazoles and 2-(N-Aryolamino)benzimidazoles

The synthesis of 2-(N-aryolamino)benzothiazoles and 2-(N-aryolamino)benzimidazoles has been accomplished in the presence of copper catalyst. These reactions involve C-S and C-N cross-coupling reaction. All electron donating and withdrawing substituent's readily underwent the reaction to give target products in good to excellent yield. In addition, the reaction also gave target product in high yield with bulk scale.

TRICYCLIC INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION

This invention relates to tricycle I and its therapeutic and prophylactic uses, wherein the variables C1, C2, Z1, Z2, Q, J, R1, and R3 are defined in the specification. Disorders treated and/or prevented include rheumatoid arthritis.