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Usage

Uses

Used in Organic Synthesis:
2-(Thiophen-3-yl)acetamide is utilized as a key intermediate in organic synthesis for the preparation of a wide range of chemical compounds. Its unique structure allows for versatile chemical reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(Thiophen-3-yl)acetamide is employed as a building block for the development of new drugs. Its potential applications include the treatment of various diseases and disorders, thanks to its ability to be incorporated into the molecular structures of bioactive compounds.
Used in Medicinal Chemistry:
The unique structural properties of 2-(Thiophen-3-yl)acetamide make it an interesting target for further study in the field of medicinal chemistry. Researchers are exploring its potential to contribute to the discovery of novel therapeutic agents and to enhance our understanding of molecular interactions in drug design.

Upstream product

• 1468-83-3 1-(thiophen-3-yl)-ethanone 
• 6964-21-2 thiophen-3-yl-acetic acid 
• 13781-53-8 (thiophen-3-yl)acetonitrile 

Downstream Products

• 6964-21-2 thiophen-3-yl-acetic acid 
• 872405-12-4 thiophene-3-methylamine methyl carbamate 
• 1262304-46-0 (4-(4-(4-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-butyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid 
• 1262304-45-9 (4-(4-(3-(3-(2,5-dioxo-4-thiophen-3-yl-2,5-dihydro-1H-pyrrol-3-yl)-indol-1-yl)-propyl)-(1,2,3)triazol-1-yl)-phenyl)-acetic acid 

Relevant academic research and scientific papers

Nitrile Hydration Reaction Using Copper Iodide/Cesium Carbonate/DBU in Nitromethane-Water

The catalytic nitrile hydration (amide formation) in a copper iodide/cesium carbonate/1,8-diazabicyclo[5.4.0]undec-7-ene/nitromethane-water system is described. The protocol is robust and reliable; it can be applied to a broad range of substrates with high chemoselectivity.

Supported Gold Nanoparticles-Catalyzed Microwave-Assisted Hydration of Nitriles to Amides under Base-Free Conditions

Polystyrene-supported gold (Au@PS) nanoparticles were synthesized by the reduction deposition approach and well characterized by UV-visible, XRD, TEM, SAED, EDX, and XPS studies. The Au@PS was applied as catalyst for the hydration of nitriles to amides in water under microwave irradiation. Several functionalized aromatic, heterocyclic and aliphatic nitriles were found to be active for synthesis of the corresponding amides where no activation of water by base, ligand and support is needed. Easy recovery, negligible leaching and recyclability for up to eight runs are added advantages of the catalyst under water-mediated reaction conditions. (Figure presented.).

Direct catalytic formation of primary and tertiary amides from non-activated carboxylic acids, employing carbamates as amine source

The operationally simple titanium(IV)- or zirconium(IV)-catalyzed direct amidation of non-activated carboxylic acids with ammonium carbamates generates primary, and tertiary N,N-dimethyl-substituted amides in good to excellent yields. Copyright