1378303-40-2Relevant academic research and scientific papers
N-alkylations of NH-sulfoximines and NH-sulfondiimines with alkyl halides mediated by potassium hydroxide in dimethyl sulfoxide
Hendriks, Christine M. M.,Bohmann, Rebekka A.,Bohlem, Marina,Bolm, Carsten
supporting information, p. 1847 - 1852 (2014/06/09)
A general method for the N-alkylation of NH-sulfoximines and NH-sulfondiimines has been developed, employing alkyl bromides with KOH in DMSO at room temperature. A variety of previously inaccessible N-alkylated sulfoximines and sulfondiimines was prepared in good to excellent yields (up to 97%). As an application, the conditions were used to access the biologically active Suloxifen.
Synthesis of sulfondiimines by N-chlorosuccinimide-mediated oxidative imination of sulfiliminium salts
Candy, Mathieu,Guyon, Carole,Mersmann, Stefanie,Chen, Jia-Rong,Bolm, Carsten
, p. 4440 - 4443 (2012/06/18)
Access to sulfondiimines: The oxidative one-pot chlorination-imination sequence of in situ generated free sulfilimines by N-chlorosuccinimide (NCS) allows the preparation of N-monosubstituted sulfondiimines under mild reaction conditions with excellent functional-group tolerance (see scheme; Mes=2,4,6-trimethylphenylsulfonyl) Copyright
