1378313-91-7Relevant academic research and scientific papers
Kinetic resolution of (±)-diethyl- and dibenzyl hydroxy(phenyl) methanephosphonates and their acyl derivatives with lipases
Malinowska, Barbara,Majewska, Paulina,Szatkowski, Pawel,Kafarski, Pawel,Lejczak, Barbara
experimental part, p. 271 - 277 (2012/03/27)
A wide variety of commercially available lipases and microbial whole cells were tested for biotransformations of (±)-diethyl and dibenzyl hydroxyl(phenyl)methanephosphonates. Biocatalytic hydrolysis of acylated hydroxyphosphonates by whole cells of Bacillus subtilis gave optically active compounds with 95%eeS. Enantioselectivities obtained when using commercially available enzymatic preparations were less satisfactory, leading to both compounds with an enantiomeric excess in the range 15-35%. Screening lipases for their ability to acylate these phosphonates or to hydrolyze their acylated derivatives enabled selection of enzymes and organisms suitable for use in both processes.
