1378384-03-2Relevant academic research and scientific papers
Chiral phosphoric acid-catalyzed enantioselective three-component Povarov reaction using cyclic enethioureas as dienophiles: Stereocontrolled access to enantioenriched hexahydropyrroloquinolines
Dagousset, Guillaume,Retailleau, Pascal,Masson, Geraldine,Zhu, Jieping
supporting information; experimental part, p. 5869 - 5873 (2012/06/18)
Three become one: Phosphoric acid-catalyzed enantioselective three-component Povarov reactions of aldehydes, anilines, and endocyclic enethioureas have been developed (see scheme). This process afforded hexahydropyrroloquinolines in high yields with excellent diastereo- and enantioselectivities. The presence of the thiourea functionality is crucial for the enantioselectivity of the reaction. Copyright
