1378417-05-0

Basic information

• Product Name: (2R)-6-formamido-2-[(4S)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoic acid
• CAS NO: 1378417-05-0
• Molecular Weight: 363.37
• Mol File: 1378417-05-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R)-6-formamido-2-[(4S)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-6-formamido-2-[(4S)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoic acid(1378417-05-0)
• EPA Substance Registry System: (2R)-6-formamido-2-[(4S)-2-(2-hydroxyphenyl)-Δ²-1,3-oxazoline-4-carboxamido]hexanoic acid(1378417-05-0)

Safety Data

• Hazardous Substances Data: 1378417-05-0(Hazardous Substances Data)

Upstream product

• 1378235-10-9 (2R)-benzyl 2-amino-6-formamidohexanoate 
• 155880-02-7 (4S)-2-[2-hydroxyphenyl]-Δ²-1,3-oxazoline-4-carboxylic acid 
• 1378235-08-5 (2R)-benzyl 2-({[(9H-fluoren-9-yl)methyloxy]carbonyl}amino)-6-formamidohexanoate 
• 1378235-06-3 (2R)-({[(9H-fluoren-9-yl)methyloxy]carbonyl}amino)-6-formamidohexanoic acid 
• 110990-08-4 N_α-(9H-fluoren-9-ylmethoxycarbonyl)-D-lysine 
• 188743-67-1 (4S)-benzyl 2-[2-(benzyloxy)phenyl]-Δ²-1,3-oxazoline-4-carboxylate 
• 188743-65-9 (S)-benzyl 2-(2-(benzyloxy)benzamido)-3-hydroxypropanoate 

Relevant articles and documents

Total synthesis and biological evaluation of transvalencin Z

The emerging global epidemic of drug-resistant tuberculosis has created an urgent need to identify novel therapeutic approaches for disease treatment. Transvalencin Z (1) is a natural product from Nocardia transvalensis with relatively potent and selective antimycobacterial activity against Mycobacterium smegmatis, making it an attractive target for structure-activity and mechanism of action studies. The total synthesis of the four possible diastereomers of transvalencin Z was completed (1a-d), and the absolute configurations were defined using chemical synthesis, HPLC retention times, and optical rotation measurements. Surprisingly, none of the transvalencin Z diastereomers exhibited any inhibitory activity against a panel of microbial pathogens, including several species of mycobacteria.