137848-05-6

Basic information

• Product Name: (4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one
• CAS NO: 137848-05-6
• Molecular Weight: 590.617
• Mol File: 137848-05-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one(137848-05-6)
• EPA Substance Registry System: (4R,6R,1'RS,1RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)-1-iodoethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one(137848-05-6)

Safety Data

• Hazardous Substances Data: 137848-05-6(Hazardous Substances Data)

Upstream product

• 137847-60-0 <2-(1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)ethyl>-triphenylphosphonium bromide 
• 137847-61-1 methyl (3R,1'RS)-(Z)-3-<(tert-butyldimethylsilyl)oxy>-7-(1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)-5-heptenoate 
• 121980-45-8 (3R)-(-)-methyl 3-<(tert-butyldimethylsilyl)oxy>-4-formylbutanoate 
• 137895-06-8 ethyl (E)-(1,2,3,4-tetrahydro-8-methoxy-1-naphthylidene)acetate 
• 137868-50-9 1-(2-bromoethyl)-1,2,3,4-tetrahydro-7-methoxynaphthalene 
• 27532-26-9 ethyl (1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)acetate 
• 27532-27-0 2-(1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)ethanol 
• 6836-19-7 7-Methoxy-1-tetralone 
• 90613-44-8 methyl 3-acetoxypentanedioate 
• 7250-55-7 dimethyl 3-hydroxypentanedioate 
• 137848-03-4 (3R,1'RS)-(Z)-3-<(tert-butyldimethylsilyl)oxy>-7-(1,2,3,4-tetrahydro-7-methoxy-1-naphthyl)-5-heptenoic acid 

Downstream Products

• 137848-10-3 (4R,6S,1'RS)-4-hydroxy-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)ethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 137848-10-3 (4R,6R,1'RS)-4-hydroxy-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)ethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 137848-07-8 (4R,6S,1'RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)ethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 137848-07-8 (4R,6R,1'RS)-4-<(tert-butyldimethylsilyl)oxy>-6-<2-(1,2,3,4-tetrahydro-7-phenyl-1-naphthyl)ethyl>-3,4,5,6-tetrahydro-2H-pyran-2-one 

Relevant articles and documents

Synthesis of Novel HMG-CoA Reductase Inhibitors, I Naphthalene Analogs of Mevinolin

The title compounds 2 and their corresponding (6S) epimers 18 are prepared in several steps by starting with chiral formyl ester 5, and α-tetralones 10: (1) coupling reaction with the ylide generated from 11 to yield unsaturated ester 13, (2) reduction to the corresponding alcohol 14, (3) addition of the Grignard reagent derived from 14 to formyl ester 5 to afford the hydroxy esters 16 and 17, and (4) lactonization.This procedure is also used to synthesize the β-naphthyl analogs 29 and 30.Some results obtained from HMG-CoA reductase inhibitor screening are also reported. Key Words: HMG-CoA reductase inhibitors / Naphthylacetates / Pig liver esterase / Glutarate, 3-hydroxy / Lactones