13788-94-8Relevant academic research and scientific papers
Tunable aryl alkyl ionic liquids (TAAILs) based on 1-aryl-3,5-dimethyl-1H-pyrazoles
?zdemir, Melek Canbulat,?zgün, Beytiye
, p. 314 - 321 (2017)
A series of fifteeen new 1-aryl-2,3,5-trimethylpyrazolium salts ([PhRC1pz][X], R: 4-Cl, 4-Br, 4-Me, 4-OMe, 4-NO2; C1: methyl, X: methanesulfonate [CH3SO3?], tetrafluoroborate [BF
Synthesis of imidazole-pyrazole conjugates bearing aryl spacer and exploring their enzyme inhibition potentials
Chaudhry, Faryal,Shahid, Wardah,al-Rashida, Mariya,Ashraf, Muhammad,Ali Munawar, Munawar,Ain Khan, Misbahul
, (2021)
Developing improved enzyme inhibitors is an effective therapy to counter various diseases. Aiming to build up biologically active templates, a new series of bis-diazoles conjugated with an aryl linker was designed and prepared through a convenient synthetic approach. Synthesized derivatives 6(a-m), having different substitutions at the 2nd position of the imidazole nucleus, depict the scope of present study. These compounds were characterized through spectroscopic methods and further examined for their in vitro enzyme inhibitory potentials against two selected enzymes: α-glucosidase and lipoxygenase (LOX). Overall, this series was found to be effective against α-glucosidase and moderately active against LOX enzyme. Compound 6k was the most potent α-glucosidase inhibitor with IC50 = 54.25 ± 0.67 μM as compared to reference drug acarbose (IC50 = 375.82 ± 1.76 μM). The docked conformation revealed the involvement of substituent's heteroatoms with amino acid residue Gly280 through hydrogen bonding. The most active LOX inhibitor was 6a with IC50 = 41.75 ± 0.04 μM as compared to standard baicalein (IC50 = 22.4 ± 1.3 μM). Docking model of 6a suggested the strong interaction of imidazole's nitrogen with iron atom of the active pocket of enzyme. Other features like lipophilicity, bulkiness of compounds, pi-pi interactions and/or pi-alkyl interactions also affected the inhibiting potentials of all prepared scaffolds.
Interactions between indazole derivative and magnesium cations-NMR investigations and theoretical calculations
Kujawski, Jacek,Doskocz, Marek,Popielarska, Hanna,Myka, Anna,Drabinska, Beata,Kruk, Joanna,Bernard, Marek K.
, p. 292 - 301 (2013)
The paper describes a new NMR approach for the determination of interaction sites between a heterocyclic ligand, like indazole, and magnesium ions. The method is based on the comparison of chemical shifts of indazole derivative before and after complexati
Novel 1-phenyl-1H-pyrazole derivatives and use thereof
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Paragraph 0220-0224, (2021/07/27)
The present invention provides a novel 1 -phenyl -1. H-The present invention relates to pyrazole derivatives and uses thereof. , The present invention 1 -phenyl -1 exhibits an excellent anti-proliferative effect on cancer cells. H-The present invention relates to a pyrazole derivative compound, a pharmaceutically acceptable salt thereof, a hydrate or stereoisomer thereof, a pharmaceutical composition for preventing, alleviating, or treating cancer metastasis and proliferative diseases comprising the same as an active ingredient.
A post-synthetically modified metal-organic framework for copper catalyzed denitrative C-N coupling of nitroarenes under heterogeneous conditions
Maity, Tanmoy,Ghosh, Pameli,Das, Soma,Saha, Debraj,Koner, Subratanath
, p. 5568 - 5575 (2021/04/06)
Here we report, for the first time, the Ullmann C-N coupling reaction of nitroarenes which is achieved by using a copper containing metal-organic framework (MOF) catalyst under heterogenous conditions. The ready availability of nitroarenes and their low cost have made them ideal replacements for haloarenes as electrophilic coupling partners. Notably, the reaction protocol suppresses the by-product formation in the catalytic reaction. The catalyst has been designed and synthesized by two step post-synthesis functionalization of a MOF,viz.dabco MOF-1 with a -NH2functional group (DMOF-NH2). In the post-synthetic treatment, salicylaldehyde has been used for organic modification first and then copper(ii) was successfully incorporated onto the inner surface of the porous material. The hybrid porous solid thus obtained has been employed in the catalytic C-N coupling reaction of nitroarenes with a wide variety of amines under heterogeneous conditions, which displayed very high turnover frequencies (TOF) in catalytic reactions attesting its efficacy towards theN-arylation reaction.
HBF4/ACN: A simple and efficient protocol for the synthesis of pyrazoles under ambient reaction conditions
Hazarika, Roktopol,Konwar, Manashjyoti,Damarla, Krishnaiah,Kumar, Arvind,Sarma, Diganta
, p. 329 - 337 (2020/01/08)
An efficient and novel protocol for pyrazole synthesis has been developed by using fluoroboric acid as the acid catalyst. Simple and easily available 1,3-diketone and hydrazine derivatives are taken as the substrates for this purpose. The reaction entails
Transition metal containing ionic liquid-assisted one-pot synthesis of pyrazoles at room temperature
Konwar, Manashjyoti,Elnagdy, Hanan M F,Gehlot, Praveen Singh,Khupse, Nageshwar D,Kumar, Arvind,Sarma, Diganta
, (2019/09/03)
Abstract: The feasible and one of the green ways to synthesize organic compounds especially pyrazole and its derivatives are systematically presented. The one-pot synthesis of pyrazole was achieved by condensation of various hydrazines and 1,3-diketone derivatives at room temperature using transition metal-based ionic liquids. Herein, the unique combination of Fe(III) with ionic liquid is explored and utilized as an efficient homogeneous catalyst for the synthesis of pyrazole and its derivatives. The homogenous catalyst thus synthesised was re-used up to the fourth cycle (with 90%, 88%, 84%, 78% yields respectively). Graphic abstract: Pyrazoles are synthesized in the presence of transition metal-based ionic liquids at room temperature. From the green chemistry perspective, ionic liquids are considered as green solvents which have gained remarkable attention because of its non-toxic, non-corrosive and non-flammable nature while the presence of transition metal as a part of counter anion gives it more catalytic activity. [Figure not available: see fulltext.].
Application and developing of iron-doped multi-walled carbon nanotubes (Fe/MWCNTs) as an efficient and reusable heterogeneous nanocatalyst in the synthesis of heterocyclic compounds
Sharghi, Hashem,Aboonajmi, Jasem,Mozaffari, Mozhdeh,Doroodmand, Mohammad Mahdi,Aberi, Mahdi
, (2017/11/16)
Iron-doped multi-walled carbon nanotubes (Fe/MWCNTs) is an efficient, ecofriendly and reusable heterogeneous nanocatalyst for the one-pot synthesis of heterocyclic compounds including bis-spiro piperidines, piperidines, dihydro-2-oxopyrroles, pyrazoles and diazepines at room temperature with good to excellent yields. The heterogeneous nanocatalyst was fully characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), inductively coupled plasma (ICP) and FT-IR analysis. Also, the structures of all prepared compounds were characterized by 1H NMR, 13C NMR, FT-IR, mass spectrometry (MS) and elemental analysis. The major advantages of these protocols are mild and green reaction conditions, short reaction times, clean reaction, operational simplicity, easy purification and good to excellent yields with the reusable heterogeneous nanocatalyst. The catalyst was ten recycled without significant loss of activity.
Efficient Copper-Catalyzed Synthesis of Substituted Pyrazoles at Room Temperature
Wang, Haifeng,Sun, Xiangli,Zhang, Shuangling,Liu, Guanglu,Wang, Chunjie,Zhu, Lili,Zhang, Hui
supporting information, p. 2689 - 2692 (2018/12/14)
An efficient method for the synthesis of pyrazoles through a copper-catalyzed condensation reaction has been developed. The new catalytic system not only maintained a broad substrate scope but was also active under acid-free reaction conditions, overcoming the conventional requirement for an acid-catalyzed system. Furthermore, the copper catalyst enabled this reaction to be performed at room temperature and in a short reaction time.
Design and Performance Validation of a Conductively Heated Sealed-Vessel Reactor for Organic Synthesis
Obermayer, David,Znidar, Desiree,Glotz, Gabriel,Stadler, Alexander,Dallinger, Doris,Oliver Kappe
, p. 11788 - 11801 (2016/12/09)
A newly designed robust and safe laboratory scale reactor for syntheses under sealed-vessel conditions at 250 °C maximum temperature and 20 bar maximum pressure is presented. The reactor employs conductive heating of a sealed glass vessel via a stainless steel heating jacket and implements both online temperature and pressure monitoring in addition to magnetic stirring. Reactions are performed in 10 mL borosilicate vials that are sealed with a silicone cap and Teflon septum and allow syntheses to be performed on a 2-6 mL scale. This conductively heated reactor is compared to a standard single-mode sealed-vessel microwave instrument with respect to heating and cooling performance, stirring efficiency, and temperature and pressure control. Importantly, comparison of the reaction outcome for a number of different synthetic transformations performed side by side in the new device and a standard microwave reactor suggest that results obtained using microwave conditions can be readily mimicked in the operationally much simpler and smaller conventionally heated device.
