1378873-17-6

Basic information

• Product Name: (3R,4S)-1-((tert-butyldimethylsilyl)oxy)-4-methylhex-5-en-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate
• CAS NO: 1378873-17-6
• Molecular Weight: 460.609
• Mol File: 1378873-17-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R,4S)-1-((tert-butyldimethylsilyl)oxy)-4-methylhex-5-en-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-1-((tert-butyldimethylsilyl)oxy)-4-methylhex-5-en-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate(1378873-17-6)
• EPA Substance Registry System: (3R,4S)-1-((tert-butyldimethylsilyl)oxy)-4-methylhex-5-en-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate(1378873-17-6)

Safety Data

• Hazardous Substances Data: 1378873-17-6(Hazardous Substances Data)

Upstream product

• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 73842-99-6 3-tert-butyldimethylsilyloxy-1-propanol 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 

Relevant articles and documents

Spiroacetal formation through telescoped cycloaddition and carbon-hydrogen bond functionalization: Total synthesis of bistramide A

Spiroacetals can be formed through a one-pot sequence of a hetero-Diels-Alder reaction an oxidative carbon-hydrogen bond cleavage and an acid treatment. This convergent approach expedites access to a complex molecular subunit which is present in numerous biologically active structures. The utility of the protocol is demonstrated through its application to a brief synthesis of the actin-binding cytotoxin bistramideA.