73842-99-6

Basic information

• Product Name: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL
• Synonyms: AKOS 90371;3-(T-BUTYLDIMETHYLSILOXY)PROPANOL;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANOL;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]PROPANOL;3-(TERT-BUTYLDIMETHYLSILOXY)PROPANOL;3-(T-Butyldimethylsiloxy)propan-1-ol;3-(tert-ButyldiMethylsilanyloxy)propan-1-ol;3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1-propanol
• CAS NO: 73842-99-6
• Molecular Formula: C₉H₂₂O₂Si
• Molecular Weight: 190.36
• Product Categories: Miscellaneous Reagents;Alcohols;C9 to C30;Oxygen Compounds
• Mol File: 73842-99-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 110 °C6 mm Hg(lit.)
• Flash Point: 199 °F
• Appearance: /
• Density: 0.892 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0292mmHg at 25°C
• Refractive Index: n20/D 1.4350(lit.)
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ether, Ethyl Acetate, Hexane, Methanol
• PKA: 14.87±0.10(Predicted)
• CAS DataBase Reference: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL(73842-99-6)
• EPA Substance Registry System: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL(73842-99-6)

Safety Data

• WGK Germany: 3
• TSCA: No
• Hazardous Substances Data: 73842-99-6(Hazardous Substances Data)

Usage

Chemical Properties

Clear Colourless Liquid

General Description

3-((tert-Butyldimethylsilyl)oxy)-propanol (3-[(tert-butyldimethylsilyl)oxy]-1-propanol) is formed as an intermediate during the synthesis of 3-(tert-butyldimethylsilyl)oxy]propanal.

InChI:InChI=1/C9H22O2Si/c1-9(2,3)12(4,5)11-8-6-7-10/h10H,6-8H2,1-5H3

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 504-63-2 trimethyleneglycol 
• 203738-77-6 3-tert-butyldimethylsilyloxy-1-propyl benzyl ether 

Downstream Products

• 89922-82-7 3-(tert-butyldimethylsilanyloxy)propionaldehyde 
• 149797-92-2 1-(3'-trimethylstannyl-5'-bromophenyl)-3-(3-hydroxypropyl) imidazolium triflate 
• 157730-91-1 (tert-butyl)dimethyl(3-(trityloxy)propoxy)silane 
• 94844-33-4 ethyl (E)-5-((tert-butyldimethylsilyl)oxy)pent-2-enoate 
• 1579954-55-4 C₂₄H₃₆O₅Si 
• 1579954-56-5 (4R,Z)-4-benzyloxy-6-(tert-butyldimethylsilyloxy)-1-(tetrahydropyran-2-yloxy)-hex-2-ene 
• 1579954-61-2 (4R,E)-4-(benzyloxy)-6-(tert-butyldimethylsilyloxy)-1-(tetrahydropyran-2-yloxy)-2-hexene 
• 1430413-00-5 1-(3-((tert-butyldimethylsilyl)oxy)propoxy)cyclohexanecarbonitrile 
• 1378873-17-6 (3R,4S)-1-((tert-butyldimethylsilyl)oxy)-4-methylhex-5-en-3-yl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoate 
• 1337571-69-3 (+/-)-[1,1,1-d3]-4-(tert-butyldimethylsilyloxy)-2-(p-toluenesulfonyloxy)butane 
• 1056016-21-7 3-((tert-butyldimethylsilyl)oxy)propyl benzoate 
• 171857-02-6 trans-1-(benzyloxy)-5-(t-butyldimethylsilyloxy)-2-pentene 

Relevant articles and documents

Functional analysis of an aspartate-based epoxidation catalyst with amide-to-alkene peptidomimetic catalyst analogues

Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The structure-dependent catalytic behavior of these isosteric peptides provides mechanistic insights in their mode of action. (Chemical Equation Presented).

A remarkable solvent effect toward the Pd/C-catalyzed cleavage of silyl ethers

Selective hydrogenation conditions of olefin, benzyl ether and acetylene functionalities in the presence of TBDMS or TES ether have been developed.

Selective acceleration for deprotection of benzyl ethers with ti-HMS

Ti-HMS, a Ti-loaded hexagonal mesoporous silica, was found to accelerate deprotection of benzyl ethers under hydrogenolytic conditions with palladium catalyst. Such acid-sensitive functional groups as silyl ether and acetal moieties in the molecule were little affected by Ti-HMS, which possesses Lewis acid sites due to Ti-atom.