73842-99-6

Basic information

• Product Name: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL
• Synonyms: AKOS 90371;3-(T-BUTYLDIMETHYLSILOXY)PROPANOL;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]-1-PROPANOL;3-[(TERT-BUTYLDIMETHYLSILYL)OXY]PROPANOL;3-(TERT-BUTYLDIMETHYLSILOXY)PROPANOL;3-(T-Butyldimethylsiloxy)propan-1-ol;3-(tert-ButyldiMethylsilanyloxy)propan-1-ol;3-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-1-propanol
• CAS NO: 73842-99-6
• Molecular Formula: C₉H₂₂O₂Si
• Molecular Weight: 190.36
• Product Categories: Miscellaneous Reagents;Alcohols;C9 to C30;Oxygen Compounds
• Mol File: 73842-99-6.mol

Chemical Properties

• Boiling Point: 110 °C6 mm Hg(lit.)
• Flash Point: 199 °F
• Appearance: /
• Density: 0.892 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0292mmHg at 25°C
• Refractive Index: n20/D 1.4350(lit.)
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ether, Ethyl Acetate, Hexane, Methanol
• PKA: 14.87±0.10(Predicted)
• CAS DataBase Reference: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL(73842-99-6)
• EPA Substance Registry System: 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL(73842-99-6)

Safety Data

• WGK Germany: 3
• TSCA: No
• Hazardous Substances Data: 73842-99-6(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
3-(T-BUTYLDIMETHYLSILOXY)PROPANOL is used as an intermediate compound for the synthesis of 3-(tert-butyldimethylsilyl)oxy]propanal. Its role in this process is crucial for the production of the final product, which may have various applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL may be used as a building block for the development of new drugs or drug candidates. Its unique chemical structure could potentially be utilized in the creation of novel therapeutic agents.
Used in Research and Development:
3-(T-BUTYLDIMETHYLSILOXY)PROPANOL can also be employed in research and development settings, where it may be used to study its chemical properties, reactivity, and potential applications in various fields, including materials science, chemical engineering, and biotechnology.
Used in Material Science:
In the field of material science, 3-(T-BUTYLDIMETHYLSILOXY)PROPANOL could be used as a component in the development of new materials with specific properties, such as improved stability, reactivity, or biocompatibility.

InChI:InChI=1/C9H22O2Si/c1-9(2,3)12(4,5)11-8-6-7-10/h10H,6-8H2,1-5H3

Upstream product

• 203738-77-6 3-tert-butyldimethylsilyloxy-1-propyl benzyl ether 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 504-63-2 trimethyleneglycol 

Downstream Products

• 89922-82-7 3-(tert-butyldimethylsilanyloxy)propionaldehyde 
• 78878-05-4 1-iodo-3-(tert-butyldimethylsilyloxy)propane 
• 566202-97-9 (3R,2'R,3'R)-3-[3'-{(3''-acetoxypropyl)-[4''-(tert-butyldiphenylsilanyloxy)butyl]carbamoyl}-2'-(4''-benzyloxyphenyl)-2',3'-dihydrobenzofuran-5'-yl]-3-(2''-nitrobenzenesulfonyl-[3'-(tert-butyldimethylsilanyloxy)propyl]amino)propionic acid methyl ester 
• 873850-80-7 Acetic acid (2S,4R,5R,6S,10R,11S)-2-(2-benzyloxy-ethyl)-10-(tert-butyl-dimethyl-silanyloxy)-5,11-dimethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester 
• 873850-75-0 Acetic acid (2S,4R,5R,6S,10R,11S)-10-(tert-butyl-dimethyl-silanyloxy)-5,11-dimethyl-2-phenethyl-1,7-dioxa-spiro[5.5]undec-4-yl ester 
• 908256-51-9 7-[3-(tert-butyldimethylsilyloxy)propylamino]-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one 
• 836598-94-8 (Z)-1-(tert-butyldimethylsilyloxy)-7-(tosyloxy)hept-4-en-3-ol 
• 519002-88-1 5-[3-(tert-butyldimethylsilyloxy)-propane-1-sulfonyl]-1-phenyl-1H-tetrazole 
• 118635-66-8 (E)-5-((tert-butyldimethylsilyl)oxy)pent-2-en-1-al 
• 143677-70-7 (S)-2-[(E)-(S)-5-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-pent-2-enyl]-octanoic acid (1R,2S)-2-dimethylamino-1-phenyl-propyl ester 
• 149797-92-2 1-(3'-trimethylstannyl-5'-bromophenyl)-3-(3-hydroxypropyl) imidazolium triflate 
• 157730-91-1 (tert-butyl)dimethyl(3-(trityloxy)propoxy)silane 
• 1178887-86-9 tert-butyl(3-(4-methoxyphenoxy)propoxy)dimethylsilane 
• 94844-33-4 ethyl (E)-5-((tert-butyldimethylsilyl)oxy)pent-2-enoate 

Relevant articles and documents

Functional analysis of an aspartate-based epoxidation catalyst with amide-to-alkene peptidomimetic catalyst analogues

Subtle exchange: Replacement of an amide function with alkene or fluoroalkene groups provides a new class of epoxidation catalysts (see scheme). The structure-dependent catalytic behavior of these isosteric peptides provides mechanistic insights in their mode of action. (Chemical Equation Presented).

Deprotection of a silyl group with mesoporous silica

The triethylsilyl (TES) group of silyl ethers of several types is selectively and easily removed in the presence of a t-butyldimethylsilyl (TBDMS) group with a mesoporous silica MCM-41/MeOH heterogeneous system. Comparison of the efficiency was carried out among several solvents, and among such promoters as common zeolites and ion-exchange resins. Furthermore, FSM-16, another mesoporous silica, was examined for the possibility of recycling by re-calcination at 400°C after the reaction.

A remarkable solvent effect toward the Pd/C-catalyzed cleavage of silyl ethers

Selective hydrogenation conditions of olefin, benzyl ether and acetylene functionalities in the presence of TBDMS or TES ether have been developed.

Selective deprotection of triethylsilyl group in the presence of t-butyldimethylsilyl group with MCM-41/MeOH heterogeneous system

Triethylsilyl (TES) group of silyl ethers of several types is selectively and easily removed in the presence of t-butyldimethylsilyl group (TBS) with a mesoporous silica MCM-41/MeOH heterogeneous system. Comparison of the efficiency was carried out among several solvents, and among such promoters as common zeolites and ion-exchange resins. Thieme Stuttgart.

Selective acceleration for deprotection of benzyl ethers with ti-HMS

Ti-HMS, a Ti-loaded hexagonal mesoporous silica, was found to accelerate deprotection of benzyl ethers under hydrogenolytic conditions with palladium catalyst. Such acid-sensitive functional groups as silyl ether and acetal moieties in the molecule were little affected by Ti-HMS, which possesses Lewis acid sites due to Ti-atom.