1378893-33-4

Basic information

• Product Name: 2-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-3-(3-mercapto-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)thiazolidin-4-one
• CAS NO: 1378893-33-4
• Molecular Weight: 484.99
• Mol File: 1378893-33-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-3-(3-mercapto-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)thiazolidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-3-(3-mercapto-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)thiazolidin-4-one(1378893-33-4)
• EPA Substance Registry System: 2-(3-(4-chlorophenyl)-1H-pyrazol-4-yl)-3-(3-mercapto-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)thiazolidin-4-one(1378893-33-4)

Safety Data

• Hazardous Substances Data: 1378893-33-4(Hazardous Substances Data)

Upstream product

• 350997-67-0 3-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde 
• 4461-15-8 4-amino-5-phenoxymethyl-4H-1,2,4-triazole-3-thiol 
• 1258254-16-8 C₁₉H₁₅ClN₆OS 
• 68-11-1 mercaptoacetic acid 

Relevant articles and documents

Synthesis, characterization, anticancer, and antioxidant activity of some new thiazolidin-4-ones in MCF-7 cells

There are limited studies centring on the potential of thiazolidin-4-ones as anticancer agents. In this study, a new series of 2-(3-substituted-1H- pyrazol-4-yl)-3-(3-substituted-5-sulfanyl-1,2,4-triazol-4-yl)-1, 3-thiazolidin-4-one (4a-o) have been synthesized by cyclo-condensation reaction of 5-substituted-4-[(3-substituted-1H-pyrazol-4-ylmethylidene)amino]-2H-1,2,4- triazole-3-thione (3a-o) and thioglycolic acid. The structures of all the synthesized compounds were confirmed by elemental analysis, spectral techniques like IR, 1H NMR, and mass spectroscopy. Few compounds exhibited dose-dependent cytotoxic effect in MTT assay in human breast cancer (MCF-7) cells. Apoptotic degradation of DNA due to action of potent thiazolidin-4-ones was analysed by agarose gel electrophoresis and visualized by ethidium bromide staining (comet assay). A concentration-dependent increase in tail length and olive tail moment was observed when treated with thiazolidin-4-ones. In vitro antioxidant studies like DPPH and ABTS-free radical scavenging assays-indicated moderate activity of thiazolidin-4-ones.