350997-67-0

Basic information

• Product Name: 3-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: ART-CHEM-BB B000242;CHEMBRDG-BB 4300299;AKOS B000242;AKOS PAO-0295;3-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE;TIMTEC-BB SBB009160;3-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde(SALTDATA: FREE);3-(4-chlorophenyl)-2H-pyrazole-4-carbaldehyde
• CAS NO: 350997-67-0
• Molecular Formula: C₁₀H₇ClN₂O
• Molecular Weight: 206.63
• Mol File: 350997-67-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 142-144 °C(Solv: water (7732-18-5))
• Boiling Point: 445.021 °C at 760 mmHg
• Flash Point: 222.941 °C
• Appearance: /
• Density: 1.379 g/cm³
• Storage Temp.: 2-8°C
• PKA: 10.45±0.50(Predicted)
• CAS DataBase Reference: 3-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE(350997-67-0)
• EPA Substance Registry System: 3-(4-CHLORO-PHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE(350997-67-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 350997-67-0(Hazardous Substances Data)

Usage

General Description

3-(4-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde is a chemical compound with the molecular formula C10H7ClN2O. It is an organic compound that contains a pyrazole ring and a chlorophenyl group. 3-(4-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde is commonly used in the synthesis of various pharmaceuticals and agrochemicals due to its potential biological activities. It has been studied for its potential applications in the treatment of cancer, inflammation, and other diseases. Additionally, 3-(4-Chloro-phenyl)-1H-pyrazole-4-carbaldehyde is also used as an intermediate in the production of other organic compounds. Overall, this chemical compound has a wide range of potential applications in the fields of medicine and chemistry.

Upstream product

• 120445-85-4 C₉H₁₀ClN₃O 
• 68-12-2 N,N-dimethyl-formamide 
• 7575-74-8 p-chloroacetophenone semicarbazone 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 1187037-79-1 C₁₅H₁₅ClN₆S 
• 1346239-62-0 diethyl 4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1346239-74-4 dimethyl 4-[3-(4-chlorophenyl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1258254-16-8 C₁₉H₁₅ClN₆OS 
• 1258254-27-1 C₁₉H₁₄Cl₂N₆OS 
• 956373-98-1 1-benzyl-3-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde 
• 304477-43-8 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities

As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane diterpenoid derivatives were designed and synthesized based combination principles, including pyrazole, thiazole and furoxan moieties. Biological evaluation indicated t

Synthesis and biological evaluation of some pyrazole derivatives, containing (Thio) semicarbazide, as dual anti-inflammatory antimicrobial agents

Background: Several series of pyrazole derivatives containing (thio) semicarbazide (4a-4h, 5a-5l, 6a-6f, 7a-7c) were designed and synthesized to screen dual inflammatory and antimicrobial activities. Methods: The products were characterized by1

Synthesis and the interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with telomeric DNA as lung cancer inhibitors

A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed, synthesized and evaluated for their antitumor activity against lung adenocarcinoma by CCK-8 assay, electrophoretic mobility shift assay (EMSA), UV-melting study, wound healing assay and docking study. These compounds showed good inhibitory activities against lung adenocarcinoma. Especially compound 12c exhibited potential antiproliferative activity against A549?cell line with the half maximal inhibitory concentration (IC50) value of 1.48?μM, which was a more potent inhibitor than cisplatin (IC50?=?12.08?μM) and leading compound 2 (IC50?=?1.69?μM), and the maximum cell inhibitory rate being up to 98.40%. Moreover, further experiments demonstrated that compounds 12a–d can strongly interact with telomeric DNA to stabilize G-quadruplex DNA with increased ΔTm values from 12.44 to 20.54?°C at a ratio of DNA to compound 1:10. These results implied that growth inhibition of A549?cells mediated by these phenanthroline derivatives is possibly positively correlated to the fact their interaction with telomeric G-quadruplexs.