13789-05-4Relevant academic research and scientific papers
Nano-SnCl4 /SiO2 as a catalyst for one-pot synthesis of substituted 1h-pyrazoles as antifungal and cytotoxic agents
Faghih, Zeinab,Khabnadideh, Soghra,Mirjalili, Bi Bi Fatemeh,Moradi, Hadi,Zamani, Leila,Zomorodian, Kamiar
, p. 459 - 465 (2020/04/21)
A simple and efficient method was developed for the synthesis of pyrazole derivatives via a one-pot reaction of 1,3-diketone and substituted hydrazines in the presence of nano-SnCl4/SiO2 as a mild catalyst. A series of some pyrazole derivatives (P1-P11) was synthesized and evaluated as anti-fungal and anti-cancer agents. Compounds P10 and P11 were demonstrated. The antimicrobial activities of the synthetic compounds showed that compounds P10 and P11 most excellently inhibited the growth of dermatophytes or Aspergillus species, respectively. Therefore, the cytotoxic activities of the-se compounds on two human cancer cell lines, A549 (lung cancer) and MCF-7 (breast cancer) were further assessed. Hence, results demonstrated that beside antifungal activity, P10 had also desirable cy-totoxic effect on investigated cancerous cell lines, even higher than cisplatin.
Nano-TiO2: An efficient and reusable catalyst for the synthesis of 1,3,5-substituted pyrazoles
Akbari, Ali,Mirjalili, Bibi Fatemeh
, p. 119 - 123 (2016/07/15)
(Formula presented) A Nano-TiO2 is an efficient catalysis for the synthesis of 1,3,5-substituted pyrazoles via condensation of 1,3- diketones and hydrazines. Simple procedure, mild heating, solvent free, high yielding, and easy workup are some advantages of this protocol. The catalyst can be recovered easily and reused many times without significant loss in catalytic activity and selectivity.
A modified and practical synthetic route to indazoles and pyrazoles using tungstate sulfuric acid
Rahmatzadeh, S. Setareh,Karami, Bahador,Khodabakhshi, Saeed
, p. 17 - 20 (2015/02/19)
Tungstate sulfuric acid-catalyzed Knorr reaction have been used as a simple, rapid, atom economic and green method for the synthesis of indazole and pyrazole derivatives based on the condensation of hydrazine derivatives and ss-dicarbonyl compounds under solvent-free conditions. It was found that the catalyst could be recovered and reused without significant loss of its activity. The use of this method provides a novel and improved modification of Knorr synthesis in terms of clean reaction profile, use of a safe catalyst and solvent-free conditions. A green method for the synthesis of indazole and pyrazole derivatives from the condensation of hydrazine derivatives with dicarbonyl compounds has been described. Tungstate sulfuric acid (TSA) catalyzed efficiently the reactions to give good yields.
Layered zirconium sulfophenyl phosphonate as heterogeneous catalyst in the synthesis of pyrazoles and 4,5,6,7-tetrahydro-1(2)H-indazoles
Curini, Massimo,Rosati, Ornelio,Campagna, Valerio,Montanari, Francesca,Cravotto, Giancarlo,Boccalini, Mauro
, p. 2927 - 2930 (2007/10/03)
Pyrazoles and tetrahydroindazoles may be prepared by condensation of 1,3-diones and hydrazines under layered zirconium sulfophenyl phosphonate catalysis, in solvent-free conditions. Georg Thieme Verlag Stuttgart.
