137890-05-2

Basic information

• Product Name: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)
• Synonyms: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI);5-Acetyl-1-methylpyrazole;1-(1-Methyl-1H-pyrazol-5-yl)
• CAS NO: 137890-05-2
• Molecular Formula: C6H8N2O
• Molecular Weight: 124.14052
• Product Categories: ACETYLGROUP
• Mol File: 137890-05-2.mol

Chemical Properties

• Boiling Point: 221 °C at 760 mmHg
• Flash Point: 87.4 °C
• Appearance: light yellow to dark yellow liquid
• Density: 1.11 g/cm³
• Vapor Pressure: 0.11mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)(137890-05-2)
• EPA Substance Registry System: Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)- (9CI)(137890-05-2)

Safety Data

• Hazardous Substances Data: 137890-05-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis Industry:
Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)(9CI) is used as a building block for the synthesis of other organic compounds due to its unique chemical structure and reactivity. Its presence in the class of pyrazoles provides a versatile platform for the development of new molecules with potential applications in various fields.
Used in Pharmaceutical Industry:
Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)(9CI) may be used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its heterocyclic nature and the presence of a ketone group can be exploited to create novel drug candidates with potential therapeutic properties.
Used in Agrochemical Industry:
Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)(9CI) could be utilized in the development of agrochemicals, such as pesticides or herbicides, due to its potential reactivity and ability to form stable derivatives. Its unique structure may contribute to the creation of new active ingredients with improved efficacy and selectivity.
Used in Material Science:
Ethanone, 1-(1-methyl-1H-pyrazol-5-yl)(9CI) may also find applications in material science, where its chemical properties can be harnessed to develop new materials with specific characteristics, such as improved stability, conductivity, or other desirable properties.

InChI:InChI=1/C6H8N2O/c1-5(9)6-3-4-7-8(6)2/h3-4H,1-2H3

Upstream product

• 66121-72-0 1-Methylpyrazole-5-carboxylic acid nitrile 
• 74-88-4 methyl iodide 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 
• 84547-59-1 2-methyl-2H-pyrazole-3-carbonyl chloride 
• 20583-33-9 1-(1H-pyrazol-5-yl)ethanone 
• 1339452-16-2 N-methoxy-N-methyl-2-methyl-2H-pyrazole-3-carboxamide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1616100-88-9 (R)-N-((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(1-methyl-1H-pyrazol-5-yl)butan-2-yl)-2-methylpropane-2-sulfinamide 
• 1616100-90-3 N-(((2S,4R)-2-(2,4-difluorophenyl)-4-hydroxy-4-(1-methyl-1H-pyrazol-5-yl)butan-2-yl)carbamothioyl)benzamide 
• 1616100-87-8 (R)-N-((S)-2-(2,4-difluorophenyl)-4-(1-methyl-1H-pyrazol-5-yl)-4-oxobutan-2-yl)-2-methylpropane-2-sulfinamide 

Relevant articles and documents

NITRATION OF ACETYL DERIVATIVES OF 1-METHYLPYRAZOLE

The nitration of acetyl-substituted 1-methylpyrazoles with nitric acid in 20percent oleum and in acetic anhydride was studied.Dipyrazolofuroxans are formed in the case of nitration in oleum. 4-Nitro-3-acetyl-1-methylpyrazole was obtained by nitration of 3-acetyl-1-methylpyrazole in acetic anhydride.

CYCLIC SULFAMIDE COMPOUNDS AND METHODS OF USING SAME

The present disclosure provides, in part, cyclic sulfamide compounds, and pharmaceutical compositions thereof, useful as modulators of Hepatitis B (HBV) core protein, and methods of treating Hepatitis B (HBV) infection.

Pyrimidinone Derivatives as Antimalarial Agents

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n=0 or 1 and R2 is a methyl group when n=0 and a hydrogen atom when n=1. Process for the preparation thereof and therapeutic use thereof.

4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION

Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: (I) wherein R1 and R2 are independently hydrogen, or -CH3; or R1 and R2 can join together in a ring by adding -(CH2)4-; R3 is hydrogen or C1-C3 al-kyl; Y and Z are independently a C6-C10- aryl group or a 5-10 membered heterocyclic group which can be further substituted with from 0-3 substituents selected from the group of halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino, halo C1-4 alkyl, CN, C1-C6, alkyl or cycloalkyl, C1-C6 alkoxy, -C=OC1-4 alkyl, -SO2C1-4 alkyl, and C2-C4 alkynyl; A is selected from the group of phenyl, ben-zyl, oxazolyl, thiazolyl, isoxazolyl, imidazolyl, pyrazolyl, pyridyl, pyrimidinyl, and pyrazinyl groups which can be further substituted with from 0-3 substituents selected from the group of halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino, haloC1-4 alkyl, hydroxyC1-6 alkyl, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; L is -NHCO-, or is a single bond; and L and Z to-gether can be absent

PYRIMIDINONE DERIVATIVES AS ANTIMALARIAL AGENTS

The invention relates to novel pyrimidinone-based heterocyclic compounds which are parasite growth inhibitors, having the general formula (I) in which Y is a morpholine chosen from three bridged morpholines, L is a bond or a linker, n = 0 or 1 and R2 is a methyl group when n = 0 and a hydrogen atom when n = 1. Process for the preparation thereof and therapeutic use thereof.

An efficient synthesis of isomeric 1-(1-Alkyl-1H-pyrazolyl) ethanones

A simple and versatile general method for the preparation of N-substituted 3-, 4-, or 5-acetylpyrazoles from corresponding acids via hydrolysis and decarboxylation of substituted diethyl [(1-alkyl-1H-pyrazolyl)carbonyl]malonates was developed. Title compounds were prepared in three steps without isolation of intermediates in 48-82% overall yield.